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通过一种新型的富血小板血浆激活和给药方式治疗有生育要求的薄型子宫内膜：一项干预性前瞻性队列临床研究。

Treating refractory thin endometrium through a novel way of activation and administration of Platelet-rich plasma in sexually active women: An interventional prospective cohort clinical study.

机构信息

University Hospital of Obstetrics and Gynecology in Damascus, Damascus, Syrian Arab Republic.

Children's Hospital Damascus, Damascus, Syrian Arab Republic.

出版信息

Medicine (Baltimore). 2024 Jun 14;103(24):e38554. doi: 10.1097/MD.0000000000038554.

DOI:10.1097/MD.0000000000038554
PMID:38875415
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11175857/
Abstract

A prospective cohort study investigated the effectiveness of platelet-rich plasma (PRP) infusion for refractory thin endometrium in 38 infertile patients. Patients showed significant improvement in endometrial thickness post-PRP injection, leading to successful implantation and pregnancy. The study revealed a negative correlation between antimullerian hormone (AMH) levels and the need for PRP interventions, suggesting higher ovarian reserve may reduce the necessity for repeated treatments. This implies AMH levels could serve as a prognostic indicator for treatment outcomes, aiding clinicians in optimizing protocols and reducing patient burden. Further research is needed to confirm these findings in larger and more diverse populations, along with exploring long-term reproductive success rates post-PRP treatment.

摘要

一项前瞻性队列研究调查了富血小板血浆（PRP）输注治疗 38 例难治性薄型子宫内膜的效果。患者在 PRP 注射后子宫内膜厚度明显改善，导致成功着床和妊娠。研究表明，抗苗勒管激素（AMH）水平与 PRP 干预的需求呈负相关，这表明较高的卵巢储备可能会减少重复治疗的必要性。这意味着 AMH 水平可以作为治疗结果的预后指标，帮助临床医生优化方案并减轻患者负担。需要进一步的研究来在更大和更多样化的人群中证实这些发现，并探讨 PRP 治疗后的长期生殖成功率。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/8ed76523af0d/medi-103-e38554-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/8a6fc5f1c3a2/medi-103-e38554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/62fbdeebcdac/medi-103-e38554-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/8ed76523af0d/medi-103-e38554-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/8a6fc5f1c3a2/medi-103-e38554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/62fbdeebcdac/medi-103-e38554-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e1/11175857/8ed76523af0d/medi-103-e38554-g003.jpg

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本文引用的文献

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Autologous platelet-rich plasma improves the endometrial thickness and live birth rate in patients with recurrent implantation failure and thin endometrium.富血小板血浆自体移植改善复发性种植失败薄型子宫内膜患者的子宫内膜厚度和活产率。
J Assist Reprod Genet. 2022 Jun;39(6):1305-1312. doi: 10.1007/s10815-022-02505-0. Epub 2022 May 4.
2
Research progress of endometrial receptivity in patients with polycystic ovary syndrome: a systematic review.多囊卵巢综合征患者子宫内膜容受性的研究进展：系统评价。
Reprod Biol Endocrinol. 2021 Aug 6;19(1):122. doi: 10.1186/s12958-021-00802-4.
3
Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020.
富含血小板血浆：2020 年的新性能认识和治疗考虑。
Int J Mol Sci. 2020 Oct 21;21(20):7794. doi: 10.3390/ijms21207794.
4
Management of a Thin Endometrium by Hysteroscopic Instillation of Platelet-Rich Plasma Into The Endomyometrial Junction: A Pilot Study.通过宫腔镜向子宫内膜肌层交界处注入富血小板血浆治疗薄型子宫内膜：一项初步研究。
J Clin Med. 2020 Aug 30;9(9):2795. doi: 10.3390/jcm9092795.
5
Platelet-Rich plasma as an effective alternative approach for improving endometrial receptivity - a clinical retrospective study.富血小板血浆作为改善子宫内膜容受性的有效替代方法 - 一项临床回顾性研究。
JBRA Assist Reprod. 2020 Oct 6;24(4):442-446. doi: 10.5935/1518-0557.20200026.
6
Physiology of the Endometrium and Regulation of Menstruation.子宫内膜生理学与月经调控。
Physiol Rev. 2020 Jul 1;100(3):1149-1179. doi: 10.1152/physrev.00031.2019. Epub 2020 Feb 7.
7
Intrauterine infusion of autologous platelet-rich plasma in women undergoing assisted reproduction: A systematic review and meta-analysis.宫腔内输注自体富含血小板血浆在接受辅助生殖技术治疗的妇女中的应用：系统评价和荟萃分析。
J Reprod Immunol. 2020 Feb;137:103078. doi: 10.1016/j.jri.2019.103078. Epub 2019 Dec 31.
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Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT.自体富血小板血浆对接受冻融胚胎移植患者子宫内膜扩张的影响：一项双盲随机对照试验。
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