自体富血小板血浆治疗薄型子宫内膜：一项初步研究。
Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study.
作者信息
Zadehmodarres Shahrzad, Salehpour Saghar, Saharkhiz Nasrin, Nazari Leila
机构信息
Department of Obstetrics and Gynecology, Preventive Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
JBRA Assist Reprod. 2017 Feb 1;21(1):54-56. doi: 10.5935/1518-0557.20170013.
Abstract
Endometrium is one of the main factors in pregnancy. During assisted reproductive technology (ART) treatments, some cycles are cancelled due to inadequate endometrial growth. This study was conducted to evaluate the effectiveness of platelet-rich plasma (PRP) in the treatment of thin endometrium. Ten patients with history of inadequate endometrial growth in frozen-thawed embryo transfer (FET) cycles were recruited into the study. Intrauterine infusion of PRP was performed. Endometrial thickness was assessed. Chemical and clinical pregnancies were reported. In all patients, endometrial thickness increased after PRP and embryo transfer was done in all of them. Five patients were pregnant. According to this study, it seems that PRP was effective for endometrial growth in patient with thin endometrium.
摘要
子宫内膜是影响妊娠的主要因素之一。在辅助生殖技术（ART）治疗期间，一些周期因子宫内膜生长不足而取消。本研究旨在评估富血小板血浆（PRP）治疗薄型子宫内膜的有效性。招募了10例在冻融胚胎移植（FET）周期中子宫内膜生长不足病史的患者进入研究。进行了PRP宫腔内输注。评估了子宫内膜厚度。报告了生化妊娠和临床妊娠情况。所有患者在PRP治疗后子宫内膜厚度增加，且均进行了胚胎移植。5例患者怀孕。根据本研究，PRP似乎对薄型子宫内膜患者的子宫内膜生长有效。
相似文献
1
Treatment of thin endometrium with autologous platelet-rich plasma: a pilot study.
JBRA Assist Reprod. 2017 Feb 1;21(1):54-56. doi: 10.5935/1518-0557.20170013.
2
Can autologous platelet rich plasma expand endometrial thickness and improve pregnancy rate during frozen-thawed embryo transfer cycle? A randomized clinical trial.
Taiwan J Obstet Gynecol. 2018 Dec;57(6):810-813. doi: 10.1016/j.tjog.2018.10.007.
3
Angiogenic factor-driven improvement of refractory thin endometrium with autologous platelet-rich plasma intrauterine infusion in frozen embryo transfer cycles.
Front Endocrinol (Lausanne). 2024 Sep 3;15:1431453. doi: 10.3389/fendo.2024.1431453. eCollection 2024.
4
Autologous platelet-rich plasma optimizes endometrial thickness and pregnancy outcomes in women with refractory thin endometrium of varied aetiology during fresh and frozen-thawed embryo transfer cycles.
JBRA Assist Reprod. 2022 Jan 17;26(1):13-21. doi: 10.5935/1518-0557.20210037.
5
Improved fertilization success and pregnancy outcome with autologous platelet-rich plasma treatment in unexplained infertility patients that had repeated implantation failure history.
Gynecol Endocrinol. 2019 Sep;35(9):815-818. doi: 10.1080/09513590.2019.1597344. Epub 2019 Apr 10.
6
Platelet-rich plasma infusion as an adjunct treatment for persistent thin lining in frozen embryo transfer cycles: first US experience report.
J Assist Reprod Genet. 2024 Feb;41(2):483-491. doi: 10.1007/s10815-023-02993-8. Epub 2023 Nov 24.
7
Autologous PRP therapy for thin endometrium: A self-controlled case series study across menstrual cycles.
Eur J Obstet Gynecol Reprod Biol. 2024 Aug;299:12-17. doi: 10.1016/j.ejogrb.2024.05.032. Epub 2024 May 26.
8
Autologous platelet-rich plasma infusion improves clinical pregnancy rate in frozen embryo transfer cycles for women with thin endometrium.
Medicine (Baltimore). 2019 Jan;98(3):e14062. doi: 10.1097/MD.0000000000014062.
9
Effect of Autologous Platelet-Rich Plasma Treatment on Refractory Thin Endometrium During the Frozen Embryo Transfer Cycle: A Pilot Study.
Front Endocrinol (Lausanne). 2019 Feb 14;10:61. doi: 10.3389/fendo.2019.00061. eCollection 2019.
10
Effects of autologous platelet-rich plasma on endometrial expansion in patients undergoing frozen-thawed embryo transfer: A double-blind RCT.
Int J Reprod Biomed. 2019 Jul 29;17(6):443-448. doi: 10.18502/ijrm.v17i6.4816. eCollection 2019 Jun.
引用本文的文献
1
Evaluation of adding autologous platelet-rich plasma to embryo transfer media on implantation outcomes: An RCT.
Int J Reprod Biomed. 2025 Jun 10;23(4):333-342. doi: 10.18502/ijrm.v23i4.18785. eCollection 2025 Apr.
2
Platelet-Rich Plasma Therapy in Premature Ovarian Insufficiency: A Case Series of IVF Outcomes.
Int Med Case Rep J. 2025 Jul 8;18:859-867. doi: 10.2147/IMCRJ.S527318. eCollection 2025.
3
Evaluating the Effectiveness of Platelet Rich Plasma Therapy in Enhancing Endometrial Receptivity for Women with Infertility: A Narrative Review.
J Pharm Bioallied Sci. 2025 May;17(Suppl 1):S137-S140. doi: 10.4103/jpbs.jpbs_1876_24. Epub 2025 Apr 21.
4
Platelet-rich plasma therapy for thin endometrium: a comprehensive review.
Arch Gynecol Obstet. 2025 Jun 12. doi: 10.1007/s00404-025-08077-5.
5
Platelet rich plasma for assisted reproduction: an overview of systematic reviews.
Blood Transfus. 2025 Jul-Aug;23(4):322-337. doi: 10.2450/BloodTransfus.937. Epub 2025 Apr 15.
6
Beneficial Effects of Infiltration of Platelet-Rich Plasma in the Endometrium.
Biology (Basel). 2025 Mar 21;14(4):319. doi: 10.3390/biology14040319.
7
Novel therapeutic strategies for Asherman's syndrome: Endometrial regeneration using menstrual blood-derived stem cells.
Regen Ther. 2025 Apr 5;29:328-340. doi: 10.1016/j.reth.2025.03.019. eCollection 2025 Jun.
8
Endometrial Infusion with Plasma Rich in Growth Factors (PRGF) in IVF Cycles: Randomized Clinical Trial in Very Thin Endometrium and Observational Uncontrolled Follow-Up After the Randomized Clinical Trial.
J Clin Med. 2025 Mar 13;14(6):1952. doi: 10.3390/jcm14061952.
9
Effects of autologous platelet-rich plasma intrauterine perfusion on clinical outcomes in recurrent implantation failure patients with non-thin endometrium undergoing frozen-thawed embryo transfer.
Arch Gynecol Obstet. 2025 May;311(5):1423-1433. doi: 10.1007/s00404-025-07983-y. Epub 2025 Mar 19.
10
A novel technique- subendometrial autologous platelet rich plasma injection in patients with unresponsive thin endometrium undergoing frozen-thawed embryo transfer: a prospective cohort study.
BMC Pregnancy Childbirth. 2025 Mar 17;25(1):297. doi: 10.1186/s12884-025-07400-x.
本文引用的文献
1
Efficacy of Platelet-Rich Plasma versus Hyaluronic Acid for treatment of Knee Osteoarthritis: A systematic review and meta-analysis.
Electron Physician. 2016 Mar 25;8(3):2115-22. doi: 10.19082/2115. eCollection 2016 Mar.
2
Does platelet-rich plasma decrease time to return to sports in acute muscle tear? A randomized controlled trial.
Knee Surg Sports Traumatol Arthrosc. 2017 Oct;25(10):3319-3325. doi: 10.1007/s00167-016-4129-7. Epub 2016 Apr 16.
3
Use of autologous platelet-rich plasma in complete cleft palate repair.
Laryngoscope. 2016 Jul;126(7):1524-8. doi: 10.1002/lary.25868. Epub 2016 Apr 14.
4
Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients.
J Cardiothorac Surg. 2016 Apr 12;11(1):62. doi: 10.1186/s13019-016-0452-9.
5
Autologous Platelet-rich Plasma Eye Drops in the Treatment of Recurrent Corneal Erosions.
Korean J Ophthalmol. 2016 Apr;30(2):101-7. doi: 10.3341/kjo.2016.30.2.101. Epub 2016 Mar 25.
6
Platelet-Rich Plasma in a Patient with Cerebral Palsy.
Am J Case Rep. 2015 Jul 17;16:469-72. doi: 10.12659/AJCR.893805.
7
Platelet-rich Plasma as a Potential Treatment for Noncicatricial Alopecias.
Int J Trichology. 2015 Apr-Jun;7(2):54-63. doi: 10.4103/0974-7753.160098.
8
The growing evidence for the use of platelet-rich plasma on diabetic chronic wounds: A review and a proposal for a new standard care.
Wound Repair Regen. 2015 Sep;23(5):638-43. doi: 10.1111/wrr.12317. Epub 2015 Aug 25.
9
Autologous platelet-rich plasma promotes endometrial growth and improves pregnancy outcome during in vitro fertilization.
Int J Clin Exp Med. 2015 Jan 15;8(1):1286-90. eCollection 2015.
10
Platelet-rich plasma as treatment for persistent ocular epithelial defects.
Transfus Apher Sci. 2015 Jun;52(3):300-4. doi: 10.1016/j.transci.2014.12.027. Epub 2015 Jan 14.
Zotero 插件