Ahlgren T, Berghem L, Jarstrand C, Lindquist L
Scand J Infect Dis. 1985;17(1):107-12. doi: 10.3109/00365548509070429.
Plasma fibronectin (PFN) levels were measured by radioimmunoassay in 24 normals and serially in 24 septic patients without underlying major trauma. All patients responded promptly to antibiotic therapy and none developed signs of shock or disseminated intravascular coagulation (DIC). After an initial decrease in PFN registered in most of the septic patients, the levels were normalized within 2 weeks of antibiotic treatment. The mean nadir levels of PFN were decreased (p less than 0.001) both in patients with gram-negative and gram-positive etiologies compared to the control group. Furthermore, the mean PFN value of the gram-positive group was lower (p less than 0.05) than that of the gram-negative group. It is concluded that a transient depletion of PFN is a constant finding in septic patients with a favourable outcome and that a single low PFN level alone does not justify fibronectin replacement therapy nor does it indicate a poor prognosis.
采用放射免疫分析法对24名正常人以及24名无重大基础创伤的脓毒症患者进行了血浆纤连蛋白（PFN）水平的测定，并对脓毒症患者进行了连续监测。所有患者对抗生素治疗反应迅速，均未出现休克或弥散性血管内凝血（DIC）迹象。在大多数脓毒症患者中，PFN水平最初下降后，在抗生素治疗2周内恢复正常。与对照组相比，革兰氏阴性菌和革兰氏阳性菌病因的患者PFN的平均最低点水平均降低（p<0.001）。此外，革兰氏阳性菌组的平均PFN值低于革兰氏阴性菌组（p<0.05）。得出的结论是，PFN的短暂消耗在预后良好的脓毒症患者中是一个常见现象，单一的低PFN水平既不能作为纤连蛋白替代治疗的依据，也不表明预后不良。
