Domula M, Bykowska K, Wegrzynowicz Z, Lopaciuk S, Weissbach G, Kopéc M
Eur J Pediatr. 1985 May;144(1):49-52. doi: 10.1007/BF00491925.
The concentration of plasma fibronectin was determined by Laurell's electroimmunoassay in 75 preterm or term newborns within the first 2 days of life, in 97 healthy infants aged from 3 days to 12 months, in 40 septic infants and in 38 healthy adult subjects. The mean fibronectin concentration in citrated plasma of normal adults was 318 +/- 84 ml/l. Healthy eutrophic term newborns 1-2 days old had approximately one-third of the fibronectin concentration of adults. There was no significant difference in the values between healthy term and eutrophic preterm newborns or between eutrophic and hypotrophic newborns. The plasma fibronectin increased strongly over the 1st month of life. No significant difference was observed between fibronectin levels in infant boys and girls. The values in septic newborns and septic older infants were significantly lower when compared with those of age-matched healthy controls. It is speculated that this deficiency, because of linkage to fibrin in disseminated intravascular coagulation or due to increased utilisation as a nonspecific opsonin and sequestration at sites of tissue injury, may contribute to organ failure in septicaemia.
采用劳雷尔免疫电泳法测定了75例出生后2天内的早产儿或足月儿、97例3天至12个月的健康婴儿、40例脓毒症婴儿以及38例健康成人的血浆纤连蛋白浓度。正常成年人枸橼酸盐血浆中纤连蛋白的平均浓度为318±84mg/L。1至2日龄的健康足月新生儿的纤连蛋白浓度约为成年人的三分之一。健康足月儿与健康早产儿之间或营养良好与营养不足的新生儿之间的数值无显著差异。血浆纤连蛋白在出生后的第1个月内显著升高。男婴和女婴的纤连蛋白水平无显著差异。与年龄匹配的健康对照组相比，脓毒症新生儿和脓毒症较大婴儿的纤连蛋白值显著降低。据推测，这种缺乏可能是由于与弥散性血管内凝血中的纤维蛋白相关联，或者是由于作为非特异性调理素的利用率增加以及在组织损伤部位被隔离，这可能导致败血症中的器官衰竭。
