Rodríguez-Cuartero A, Nuñez-Carrill J, Salas-Galán A, Rodríguez-Rodríguez M A
Dept. of Internal Medicine, Granada University, Spain.
Infection. 1993 Sep-Oct;21(5):303-5. doi: 10.1007/BF01712450.
Concentrations of circulating fibronectin were studied in plasma of 22 patients with acquired immunodeficiency syndrome and 24 healthy blood donors. There were significant differences between the plasma fibronectin values of the patient population with AIDS (mean 2 SD = 206 +/- 86 mg/l) and of the control group (mean +/- 2 SD = 297 +/- 92 mg/l). AIDS patients with visceral leishmaniasis showed a significant diminution of plasma fibronectin concentration (mean +/- 2 SD = 132 +/- 31 mg/l). A significant increase in plasma fibronectin concentrations was noted after 14 days of treatment with antimony (mean 2 SD = 239 +/- 67 mg/l). These results suggest that the measurement of fibronectin concentrations in patients with AIDS especially with concurrent infection, contributes to diagnosis. A significant decrease in plasma fibronectin concentrations was observed in patients with AIDS and visceral leishmaniasis.
对22例获得性免疫缺陷综合征患者和24名健康献血者的血浆中循环纤维连接蛋白浓度进行了研究。艾滋病患者群体（均值±2标准差 = 206±86毫克/升）与对照组（均值±2标准差 = 297±92毫克/升）的血浆纤维连接蛋白值之间存在显著差异。患有内脏利什曼病的艾滋病患者血浆纤维连接蛋白浓度显著降低（均值±2标准差 = 132±31毫克/升）。在用锑治疗14天后，血浆纤维连接蛋白浓度显著升高（均值±2标准差 = 239±67毫克/升）。这些结果表明，测量艾滋病患者尤其是并发感染患者的纤维连接蛋白浓度有助于诊断。在患有艾滋病和内脏利什曼病的患者中观察到血浆纤维连接蛋白浓度显著降低。
