Molecular Neuroscience Institute and Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan, USA; email:
Annu Rev Genet. 2024 Nov;58(1):67-90. doi: 10.1146/annurev-genet-111523-102000. Epub 2024 Nov 14.
Sight is one of our most precious senses. People fear losing their sight more than any other disability. Thus, restoring sight to the blind is an important goal of vision scientists. Proregenerative species, such as zebrafish, provide a system for studying endogenous mechanisms underlying retina regeneration. Nonregenerative species, such as mice, provide a system for testing strategies for stimulating retina regeneration. Key to retina regeneration in zebrafish and mice is the Müller glial cell, a malleable cell type that is amenable to a variety of regenerative strategies. Here, we review cellular and molecular mechanisms used by zebrafish to regenerate a retina, as well as the application of these mechanisms, and other strategies to stimulate retina regeneration in mice. Although our focus is on Müller glia (MG), niche components and their impact on MG reprogramming are also discussed.
视力是我们最宝贵的感觉之一。人们比其他任何残疾都更害怕失去视力。因此，恢复盲人的视力是视觉科学家的一个重要目标。像斑马鱼这样的再生物种为研究视网膜再生的内在机制提供了一个系统。非再生物种，如老鼠，则为刺激视网膜再生的策略提供了一个系统。斑马鱼和老鼠的视网膜再生的关键是 Müller 胶质细胞，这是一种可塑性细胞类型，可采用多种再生策略。在这里，我们回顾了斑马鱼用来再生视网膜的细胞和分子机制，以及这些机制的应用，以及其他刺激老鼠视网膜再生的策略。尽管我们的重点是 Müller 胶质细胞（MG），但也讨论了小生境成分及其对 MG 重编程的影响。
