College of Education, National Tsing Hua University, Hsinchu City, Taiwan; Research Center for Education and Mind Sciences, National Tsing Hua University, Hsinchu City, Taiwan; Basic Psychology Group, Department of Educational Psychology and Counseling, National Tsing Hua University, Hsinchu City, Taiwan; Department of Kinesiology, National Tsing Hua University, Hsinchu City, Taiwan.
Cognitive Electrophysiology Laboratory, Control, Aging, Sleep, and Emotion (CASE), National Cheng Kung University, Tainan City, Taiwan; Department of Psychology, National Cheng Kung University, Tainan City, Taiwan; Institute of Allied Health Sciences, National Cheng Kung University, Tainan City, Taiwan; Department of Public Health, National Cheng Kung University, Tainan City, Taiwan.
Prog Brain Res. 2024;286:179-209. doi: 10.1016/bs.pbr.2023.11.001. Epub 2023 Dec 19.
Engaging in regular physical activity and establishing exercise habits is known to have multifaceted benefits extending beyond physical health to cognitive and mental well-being. This study explores the intricate relationship between exercise habits, brain imaging markers, and mental health outcomes. While extensive evidence supports the positive impact of exercise on cognitive functions and mental health, recent advancements in multimodal imaging techniques provide a new dimension to this exploration. By using a cross-sectional multimodal brain-behavior statistic in participants with different exercise habits, we aim to unveil the intricate mechanisms underlying exercise's influence on cognition and mental health, including the status of depression, anxiety, and quality of life. This integration of exercise science and imaging promises to substantiate cognitive benefits on mental health and uncover functional and structural changes underpinning these effects. This study embarks on a journey to explore the significance of multimodal imaging metrics (i.e., structural and functional metrics) in deciphering the intricate interplay between exercise habits and mental health, enhancing the comprehension of how exercise profoundly shapes psychological well-being. Our analysis of group comparisons uncovered a strong association between regular exercise habits and improved mental well-being, encompassing factors such as depression, anxiety levels, and overall life satisfaction. Additionally, individuals who engaged in exercise displayed enhanced brain metrics across different modalities. These metrics encompassed greater gray matter volume within the left frontal regions and hippocampus, improved white matter integrity in the frontal-occipital fasciculus, as well as more robust functional network configurations in the anterior segments of the default mode network. The interplay between exercise habits, brain adaptations, and mental health outcomes underscores the pivotal role of an active lifestyle in nurturing a resilient and high-functioning brain, thus paving the way for tailored interventions and improved well-being.
定期进行身体活动并养成锻炼习惯，已被证实对身心健康、认知和心理健康都有多种益处。本研究探讨了锻炼习惯、大脑成像标志物和心理健康结果之间的复杂关系。虽然有大量证据支持锻炼对认知功能和心理健康的积极影响，但最近多模态成像技术的进步为这一探索提供了新的维度。通过在具有不同锻炼习惯的参与者中使用跨模态脑行为统计方法，我们旨在揭示锻炼对认知和心理健康影响的复杂机制，包括抑郁、焦虑和生活质量的状况。这种锻炼科学与成像的结合有望证实锻炼对心理健康的认知益处，并揭示支持这些效果的功能和结构变化。本研究旨在探索多模态成像指标（即结构和功能指标）在解读锻炼习惯和心理健康之间复杂相互作用方面的意义，以增强对锻炼如何深刻塑造心理幸福感的理解。我们对组间比较的分析发现，定期锻炼习惯与改善心理健康之间存在很强的关联，包括抑郁、焦虑水平和整体生活满意度等因素。此外，经常锻炼的人在不同模式下的大脑指标都有所改善。这些指标包括左额区和海马体的灰质体积增加，额枕束的白质完整性改善，以及默认模式网络前区的功能网络配置更加强健。锻炼习惯、大脑适应和心理健康结果之间的相互作用突显了积极生活方式在培养具有弹性和高功能大脑方面的关键作用，为量身定制的干预措施和改善幸福感铺平了道路。
