Department of Infectious Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Department of Infectious Disease, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, China.
Sci Rep. 2024 Jun 14;14(1):13801. doi: 10.1038/s41598-024-63965-1.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a predominant liver disease worldwide, lacking approved drugs for clinical intervention at present. The composite dietary antioxidant index (CDAI) is used to assess the anti-inflammatory properties of diets, with higher CDAI indicating greater exposure to antioxidants. Therefore, our study aimed to explore the relationship between CDAI and MASLD in order to identify potential therapeutic approaches. We collected data from 12,286 participants in the National Health and Nutrition Examination Survey (NHANES) database from 2017 to 2020 for analysis. The correlation between CDAI and MASLD status, controlled attenuation parameter (CAP), and liver stiffness measurement (LSM) was evaluated by adjusting for confounding variables using weighted binary logistic regression model, linear regression model, and restricted cubic spline (RCS) regression. The median CDAI in this study was - 0.3055 (interquartile range [IQR], - 2.299 to 2.290). The CDAI was higher in the population characterized by being young, female, higher income, absence of diabetes, and non-MASLD. After multivariable adjustment, the results of the weighted linear regression model suggested that higher CDAI may be associated with a decrease in CAP values; the results of the RCS regression model indicated significant non-linear relationships between MASLD status, CAP, LSM, and CDAI. The CDAI corresponding to the inflection points of the relationship curves between MASLD status, CAP, LSM, and CDAI were 0.349, 0.699, and 0.174, respectively. After further stratification by gender, we found that the relationship between MASLD status, CAP, and CDAI was significantly linear for females, whereas for males, it was non-linear, and the CDAI values corresponding to the inflection points in the curves for males were 1.325 and 0.985, respectively. We found that higher CDAI may be associated with decreased CAP values, particularly significant in females, suggesting that the intake of complex dietary antioxidants may ameliorate hepatic steatosis and reduce the occurrence of MASLD. Therefore, promoting dietary patterns rich in antioxidants may be an appropriate strategy to reduce the incidence of MASLD.
代谢相关脂肪性肝病（MASLD）已成为全球主要的肝脏疾病，目前缺乏临床干预的批准药物。复合膳食抗氧化剂指数（CDAI）用于评估饮食的抗炎特性，CDAI 值越高表明抗氧化剂暴露量越大。因此，我们的研究旨在探讨 CDAI 与 MASLD 之间的关系，以确定潜在的治疗方法。我们从 2017 年至 2020 年的国家健康和营养调查（NHANES）数据库中收集了 12286 名参与者的数据进行分析。通过加权二项逻辑回归模型、线性回归模型和限制性三次样条（RCS）回归，调整混杂变量后评估 CDAI 与 MASLD 状态、受控衰减参数（CAP）和肝硬度测量（LSM）之间的相关性。本研究中 CDAI 的中位数为-0.3055（四分位距[IQR]，-2.299 至 2.290）。CDAI 在年轻、女性、收入较高、无糖尿病和非 MASLD 人群中较高。多变量调整后，加权线性回归模型的结果表明，较高的 CDAI 可能与 CAP 值降低有关；RCS 回归模型的结果表明，MASLD 状态、CAP、LSM 和 CDAI 之间存在显著的非线性关系。MASLD 状态、CAP、LSM 和 CDAI 关系曲线拐点对应的 CDAI 值分别为 0.349、0.699 和 0.174。进一步按性别分层后，我们发现女性 MASLD 状态、CAP 和 CDAI 之间的关系呈显著线性，而男性则呈非线性，曲线拐点对应的 CDAI 值分别为 1.325 和 0.985。我们发现较高的 CDAI 可能与 CAP 值降低有关，尤其是在女性中，这表明摄入复杂的膳食抗氧化剂可能改善肝脂肪变性并降低 MASLD 的发生。因此，促进富含抗氧化剂的饮食模式可能是降低 MASLD 发病率的一种适当策略。
