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大枣提取物通过依赖 DAF-16/SOD-3 延长秀丽隐杆线虫的寿命并提高其应激耐受力。

Jujubae Fructus extract prolongs lifespan and improves stress tolerance in Caenorhabditis elegans dependent on DAF-16/SOD-3.

机构信息

Department of Nutrition and Food Hygiene, College of Public Health, Xinxiang Medical University, 601 Jinsui Avenue, Xinxiang City, Henan Province, China.

Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

出版信息

Sci Rep. 2024 Jun 14;14(1):13713. doi: 10.1038/s41598-024-64045-0.

DOI:10.1038/s41598-024-64045-0
PMID:38877105
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11178930/
Abstract

Jujubae Fructus, the fruit of Ziziphus jujuba Mill has been used as one of the medicine food homology species for thousands of years in China. Studies have shown that the active ingredients of Jujubae Fructus have a variety of biological effects, but its role in the aging process still lacks knowledge. Here, we investigated the effect of Jujubae Fructus extract (JE) on Caenorhabditis elegans lifespan and its potential mechanism. The lifespan of C. elegans treated with JE was signifificantly increased in a dose-dependent manner. In addition, JE treatment prolonged the reproductive period and increased normal activity during aging in C. elegans. Similarly, JE supplementation also enhanced the resistance to heat and oxidative stress in C. elegans. Furthermore, the mutant worms' lifespan assays demonstrated that JE requires daf-16 to prolong lifespan. DAF-16::GFP analysis of TJ356 showed that JE treatment translocates DAF-16::GFP to nucleus in transgenic worms. By analyzing the downstream of daf-16, we identify that JE may regulate sod3 downstream of daf-16. Mutant worms' lifespan and transgenic reporter gene expression assays revealed that increasing SOD-3 expression was critical for extending longevity in C. elegans with JE therapy. Collectively, these data indicate that JE may have an important role in C. elegans longevity that is dependent on DAF-16 and SOD-3.

摘要

大枣，即枣属植物的果实，在中国作为药食同源物种已有数千年的历史。研究表明，大枣的活性成分具有多种生物作用，但它在衰老过程中的作用仍缺乏相关知识。在这里，我们研究了大枣提取物（JE）对秀丽隐杆线虫寿命的影响及其潜在机制。结果表明，JE 处理以剂量依赖的方式显著延长了秀丽隐杆线虫的寿命。此外，JE 处理还延长了秀丽隐杆线虫的生殖期，并增加了衰老过程中的正常活动。同样，JE 补充也增强了秀丽隐杆线虫对热和氧化应激的抵抗力。进一步的，突变体蠕虫寿命测定表明 JE 需要 daf-16 来延长寿命。TJ356 的 DAF-16::GFP 分析表明，JE 处理将 DAF-16::GFP 转运到转基因蠕虫的核内。通过分析 daf-16 的下游，我们确定 JE 可能通过调节 sod3 下游的 daf-16。突变体蠕虫寿命和转基因报告基因表达测定表明，增加 SOD-3 表达对于 JE 治疗延长秀丽隐杆线虫的寿命至关重要。总之，这些数据表明 JE 可能在依赖于 DAF-16 和 SOD-3 的秀丽隐杆线虫寿命中具有重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/ce14edc29ebd/41598_2024_64045_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/8829adb96a1e/41598_2024_64045_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/051fe4370202/41598_2024_64045_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/881b69c146ad/41598_2024_64045_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/25cf9eb1162a/41598_2024_64045_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/c5245e82d5f8/41598_2024_64045_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/a217e533ec5e/41598_2024_64045_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/d3272dfe02f8/41598_2024_64045_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/412e7dc8503a/41598_2024_64045_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/ce14edc29ebd/41598_2024_64045_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/8829adb96a1e/41598_2024_64045_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/051fe4370202/41598_2024_64045_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/881b69c146ad/41598_2024_64045_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/25cf9eb1162a/41598_2024_64045_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/c5245e82d5f8/41598_2024_64045_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/a217e533ec5e/41598_2024_64045_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/d3272dfe02f8/41598_2024_64045_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/412e7dc8503a/41598_2024_64045_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7293/11178930/ce14edc29ebd/41598_2024_64045_Fig9_HTML.jpg

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