Department of Clinical Laboratory Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Department of Clinical Medicine, The Third Clinical School of Guangzhou Medical University, Guangzhou, 511436, China.
BMC Womens Health. 2024 Jun 14;24(1):341. doi: 10.1186/s12905-024-03200-1.
This cross-sectional study aims to explore whether there exists an interaction between selenium and menopause concerning type 2 diabetes (T2D) prevalence and its related indicators such as fasting blood glucose (FBG) and homeostasis model assessment of insulin resistance (HOMA-IR).
150 women aged 35-60 years old were finally analyzed in this study. Multivariate linear or logistic regression modeling was conducted to explore the association of selenium and the prevalence of T2D besides its related indicators. Subgroup analyses were conducted based on menopause status to assess the potential impact on the relationship.
In the fully adjusted model, serum selenium was positively associated with FBG (β: 0.03, CI: 0.01-0.05) and the prevalence of T2D (OR: 1.04, CI: 1.00-1.08). After stratifying the data by menopause status, compared with the postmenopausal women group, as the serum selenium concentrations increased, the FBG concentrations were significantly higher in the premenopausal women group (p for interaction = 0.0020).
The present study found serum selenium was positively associated with FBG and the prevalence of T2D. Furthermore, the relationship between serum selenium and FBG was different in the premenopausal and postmenopausal women. More studies are still needed in the future to verify the relationship as well as to explore the specific mechanisms.
本横断面研究旨在探讨硒与绝经状态是否存在交互作用，从而影响 2 型糖尿病（T2D）的患病率及其相关指标，如空腹血糖（FBG）和胰岛素抵抗稳态模型评估（HOMA-IR）。
本研究最终纳入了 150 名年龄在 35-60 岁的女性。采用多元线性或 logistic 回归模型来探讨硒与 T2D 患病率及其相关指标之间的关联。根据绝经状态进行亚组分析，以评估其对关系的潜在影响。
在完全调整模型中，血清硒与 FBG（β：0.03，CI：0.01-0.05）和 T2D 的患病率（OR：1.04，CI：1.00-1.08）呈正相关。按绝经状态分层数据后，与绝经后妇女组相比，随着血清硒浓度的增加，绝经前妇女组的 FBG 浓度显著升高（p 交互=0.0020）。
本研究发现血清硒与 FBG 和 T2D 的患病率呈正相关。此外，血清硒与 FBG 之间的关系在绝经前和绝经后妇女中存在差异。未来仍需要更多的研究来验证这种关系，并探讨其具体机制。
