Yan Fei, Liu Jidong, Zhao Xiangmin, Hu Xiuping, Wang Shaoyuan, Ma Zeqiang, Liang Kai, Song Jun, Wang Chuan, Hou Xinguo, Chen Shihong, Chen Li
1 Department of Endocrinology of Qilu Hospital and Institute of Endocrinology and Metabolism, Shandong University , Jinan, China .
7 Department of Poisoning and Occupational Diseases, Qilu Hospital of Shandong University , Jinan, China .
J Womens Health (Larchmt). 2015 Oct;24(10):843-8. doi: 10.1089/jwh.2014.5183. Epub 2015 Sep 29.
This study aimed to assess the prevalence of metabolic syndrome (MetS) and the association of years since menopause with MetS and Insulin Resistance (IR) in Chinese women.
A total of 4436 Chinese subjects aged 40-80 years participated in the study; 790 were premenopausal women, and 3646 were postmenopausal women. IR was arbitrarily defined as a homeostasis model assessment-IR index (HOMA-IR) value above the 75th percentile of normal glucose tolerance (NGT). MetS was defined according to the International Diabetes Federation consensus definition. To test whether there was an association between the number of years since menopause and MetS, multivariate logistic analysis was conducted. Premenopausal women were used as a comparison group in regression analyses.
After adjustment for age, body mass index (BMI), and γ-glutamyltransferase (GGT), more years since menopause was highly associated with an increased risk of MetS (p for trend <0.05) ; the number of years since menopause was not correlated with fasting insulin and HOMA-IR. Postmenopausal women with 10 to 14 years since menopause had the highest risk (odds ratio [OR], 2.10; 95% confidence interval [CI], 1.52-2.89, p < .05) of MetS, high triglycerides (TG; OR, 1.80; 95% CI, 1.34-2.42, p < .05) and high glucose (OR, 1.52; 95% CI, 1.14-2.05, p < .05) and low high-density lipoprotein cholesterol (HDL-C; OR, 1.38; 95% CI, 1.18-2.32, p < .05). Postmenopausal women with more than 15 years since menopause had the highest risk of abdominal obesity (OR, 1.69; 95% CI, 1.05-2.71, p < .05).
In China, more years since menopause was highly associated with an increased risk of MetS. Menopausal history may help identify women with increased risk of developing MetS.
本研究旨在评估中国女性代谢综合征（MetS）的患病率，以及绝经年限与MetS和胰岛素抵抗（IR）之间的关联。
共有4436名年龄在40 - 80岁的中国受试者参与了本研究；其中790名是绝经前女性，3646名是绝经后女性。IR被随意定义为稳态模型评估-IR指数（HOMA-IR）值高于正常糖耐量（NGT）的第75百分位数。MetS根据国际糖尿病联盟的共识定义来定义。为了检验绝经年限与MetS之间是否存在关联，进行了多因素逻辑分析。在回归分析中，绝经前女性被用作对照组。
在对年龄、体重指数（BMI）和γ-谷氨酰转移酶（GGT）进行调整后，绝经年限越长与MetS风险增加高度相关（趋势p<0.05）；绝经年限与空腹胰岛素和HOMA-IR无关。绝经10至14年的绝经后女性患MetS、高甘油三酯（TG；比值比[OR]，1.80；95%置信区间[CI]，1.34 - 2.42，p<0.05）、高血糖（OR，1.52；95%CI，1.14 - 2.05，p<0.05）和低高密度脂蛋白胆固醇（HDL-C；OR，1.38；95%CI，1.18 - 2.32，p<0.05）的风险最高。绝经超过15年的绝经后女性腹部肥胖风险最高（OR，1.69；95%CI，1.05 - 2.71，p<0.05）。
在中国，绝经年限越长与MetS风险增加高度相关。绝经史可能有助于识别患MetS风险增加的女性。
