National & Local Joint Engineering Research Center of Targeted and Innovative Therapeutics, College of Pharmacy, Chongqing University of Arts and Sciences, Chongqing, 402160, People's Republic of China.
Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, 30322, USA.
J Exp Clin Cancer Res. 2024 Jun 15;43(1):168. doi: 10.1186/s13046-024-03089-6.
PANoptosis represents a novel type of programmed cell death (PCD) with distinctive features that incorporate elements of pyroptosis, apoptosis, and necroptosis. PANoptosis is governed by a newly discovered cytoplasmic multimeric protein complex known as the PANoptosome. Unlike each of these PCD types individually, PANoptosis is still in the early stages of research and warrants further exploration of its specific regulatory mechanisms and primary targets. In this review, we provide a brief overview of the conceptual framework and molecular components of PANoptosis. In addition, we highlight recent advances in the understanding of the molecular mechanisms and therapeutic applications of PANoptosis. By elucidating the complex crosstalk between pyroptosis, apoptosis and necroptosis and summarizing the functional consequences of PANoptosis with a special focus on the tumor immune microenvironment, this review aims to provide a theoretical basis for the potential application of PANoptosis in cancer therapy.
细胞焦亡样程序性细胞死亡（PANoptosis）是一种新型的程序性细胞死亡（PCD），具有独特的特征，融合了细胞焦亡、细胞凋亡和细胞坏死的特征。PANoptosis 受一种新发现的细胞质多聚体蛋白复合物调控，称为 PANoptosome。与每种单独的 PCD 类型不同，PANoptosis 仍处于研究的早期阶段，需要进一步探索其特定的调节机制和主要靶点。在这篇综述中，我们简要概述了 PANoptosis 的概念框架和分子组成。此外，我们还强调了对 PANoptosis 的分子机制和治疗应用的理解的最新进展。通过阐明细胞焦亡、细胞凋亡和细胞坏死之间的复杂串扰，并总结 PANoptosis 的功能后果，特别关注肿瘤免疫微环境，本综述旨在为 PANoptosis 在癌症治疗中的潜在应用提供理论基础。
