XiangYa School of Medicine, Central South University, Changsha, Hunan, China.
School of Anesthesiology, Guizhou Medical University, Guiyang, Guizhou, China.
Front Immunol. 2023 Feb 9;14:1120034. doi: 10.3389/fimmu.2023.1120034. eCollection 2023.
PANoptosis, a new research hotspot at the moment, is a cell death pattern in which pyroptosis, apoptosis, and necroptosis all occur in the same cell population. In essence, PANoptosis is a highly coordinated and dynamically balanced programmed inflammatory cell death pathway that combines the main features of pyroptosis, apoptosis, and necroptosis. Many variables, such as infection, injury, or self-defect, may be involved in the occurrence of PANoptosis, with the assembly and activation of the PANoptosome being the most critical. PANoptosis has been linked to the development of multiple systemic diseases in the human body, including infectious diseases, cancer, neurodegenerative diseases, and inflammatory diseases. Therefore, it is necessary to clarify the process of occurrence, the regulatory mechanism of PANoptosis, and its relation to diseases. In this paper, we summarized the differences and relations between PANoptosis and the three types of programmed cell death, and emphatically expounded molecular mechanism and regulatory patterns of PANoptosis, with the expectation of facilitating the application of PANoptosis regulation in disease treatment.
细胞焦亡、细胞凋亡和细胞坏死均存在于同一细胞群体中，因此，细胞焦亡样程序性细胞死亡（PANoptosis）是目前的一个新的研究热点。从本质上讲，PANoptosis 是一种高度协调和动态平衡的程序性炎症细胞死亡途径，结合了细胞焦亡、细胞凋亡和细胞坏死的主要特征。许多变量，如感染、损伤或自身缺陷，可能参与了 PANoptosis 的发生，其中 PANoptosome 的组装和激活最为关键。PANoptosis 与人体多种全身性疾病的发生有关，包括传染病、癌症、神经退行性疾病和炎症性疾病。因此，有必要阐明 PANoptosis 的发生过程、调控机制及其与疾病的关系。本文总结了 PANoptosis 与三种程序性细胞死亡的差异和联系，并着重阐述了 PANoptosis 的分子机制和调控模式，以期促进 PANoptosis 调控在疾病治疗中的应用。
