Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Parkinsonism Relat Disord. 2024 Aug;125:107037. doi: 10.1016/j.parkreldis.2024.107037. Epub 2024 Jun 12.
To investigate interocular asymmetry (IA) of retinal structure and vessel density in patients with Parkinson's disease (PD) and normal controls (NC).
Seventy-eight subjects including 40 PD patients and 38 NC had completed optical coherence tomography angiography (OCTA) and neurological examinations for three rating scales (UPDRS-III, MMSE and MoCA). The IA was calculated by the absolute value of difference in right and left eyes. The IA of thickness in macular ganglion cell inner-plexiform layer (GCIPL), peripapillary retinal nerve fiber layer (pRNFL), and vessel density of superficial capillary plexus (SCP), deep capillary plexus (DCP), radial peripapillary capillary (RPC) were obtained from OCTA.
The motor-symptom-onset side of eyes showed lower vessel density in parafovea of SCP (51.09 ± 3.46 vs 49.81 ± 4.16, P = 0.03) and superior hemi of perifovea DCP (49.55 ± 5.81 vs 47.33 ± 5.71, = 0.04). The PD patients showed larger IA in thickness of superior half of pRNFL (5.27 [2.67, 10.87] vs 3.08 [1.62, 5.61], P = 0.02) and parafovea GCIPL (2.40[1.25, 6.35] vs 1.40[0.50, 2.45], P = 0.02). No significant interocular asymmetry was found in vessel density between PD and NC. A higher UPDRS-III scale was associated with larger IA in GCIPL (β = 0.093, P = 0.001) and smaller IA in DCP (β = -0.065, P = 0.037).
The motor-symptom-onset side of eyes showed more severe loss of macular vessel density than the other side of eyes. The PD patients showed asymmetrical structural change in GCIPL and pRNFL, which showed the potential as the diagnostic biomarker for PD.
研究帕金森病（PD）患者和正常对照（NC）的视网膜结构和血管密度的眼间不对称（IA）。
78 名受试者，包括 40 名 PD 患者和 38 名 NC，完成了光学相干断层血管造影（OCTA）和 3 项评分量表（UPDRS-III、MMSE 和 MoCA）的神经检查。通过右眼和左眼的差值绝对值计算 IA。从 OCTA 获得黄斑神经节细胞内丛状层（GCIPL）、视盘周围视网膜神经纤维层（pRNFL）厚度的 IA 以及浅层毛细血管丛（SCP）、深层毛细血管丛（DCP）、视盘周围放射状毛细血管（RPC）的血管密度。
眼睛的运动症状起始侧在 SCP 旁中心凹（51.09±3.46 比 49.81±4.16，P=0.03）和 DCP 上半旁中心凹（49.55±5.81 比 47.33±5.71，P=0.04）的血管密度较低。PD 患者的上半 pRNFL 厚度（5.27[2.67，10.87]比 3.08[1.62，5.61]，P=0.02）和 GCIPL 旁中心凹（2.40[1.25，6.35]比 1.40[0.50，2.45]，P=0.02）的 IA 更大。PD 和 NC 之间在血管密度方面没有发现明显的眼间不对称。较高的 UPDRS-III 量表与 GCIPL 较大的 IA（β=0.093，P=0.001）和 DCP 较小的 IA（β=-0.065，P=0.037）相关。
眼睛的运动症状起始侧比另一侧的黄斑血管密度损失更严重。PD 患者的 GCIPL 和 pRNFL 表现出不对称的结构变化，这可能成为 PD 的诊断生物标志物。
