Qin Shiyuan, Li Lei, Gao Shuang, Yang Yazhi, Chen Yu, Wang Ying
Department of Neurology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650031, China.
Neurol Sci. 2025 Sep 15. doi: 10.1007/s10072-025-08283-8.
Optical coherence tomography angiography (OCTA) is a novel ocular imaging technique that has garnered significant attention from neurologists due to its ability to assess retinal microvascular changes in neurodegenerative diseases. In recent years, numerous studies have reported retinal microvascular abnormalities in Parkinson's disease (PD). In this study, we employ visual analysis and meta-analysis to identify research trends regarding the application of OCTA in PD, and to evaluate the potential of retinal blood flow alterations as an early diagnostic marker for PD.
This study combines visual analysis and meta-analysis. A systematic search of PubMed, Scopus, and Web of Science identified articles on retinal microvascular changes in PD patients using OCTA. VOSviewer and CiteSpace were used to analyze keywords and trends, while RevMan 5.4 conducted the meta-analysis on eligible studies.
A total of 28 studies from the Web of Science database were included for visual analysis, revealing a growing research focus on retinal microvascular changes in PD. The meta-analysis, which incorporated 19 studies, demonstrated a significant reduction in the density of the superficial capillary plexus (SCP) in PD patients. However, findings related to the deep capillary plexus (DCP) and the foveal avascular zone (FAZ) varied across studies. Additionally, several investigations reported a correlation between microvascular density and disease severity.
The findings support the use of OCTA as a noninvasive, objective tool for the early diagnosis and monitoring of PD progression, emphasizing its potential for clinical application in the preclinical stages of the disease.
光学相干断层扫描血管造影（OCTA）是一种新型眼部成像技术，因其能够评估神经退行性疾病中的视网膜微血管变化而受到神经科医生的广泛关注。近年来，众多研究报告了帕金森病（PD）患者存在视网膜微血管异常。在本研究中，我们采用可视化分析和荟萃分析来确定OCTA在PD应用方面的研究趋势，并评估视网膜血流改变作为PD早期诊断标志物的潜力。
本研究结合了可视化分析和荟萃分析。通过对PubMed、Scopus和Web of Science进行系统检索，确定了使用OCTA研究PD患者视网膜微血管变化的文章。使用VOSviewer和CiteSpace分析关键词和趋势，同时使用RevMan 5.4对符合条件的研究进行荟萃分析。
共纳入来自Web of Science数据库的28项研究进行可视化分析，结果显示对PD视网膜微血管变化的研究关注度不断增加。纳入19项研究的荟萃分析表明，PD患者浅表毛细血管丛（SCP）密度显著降低。然而，关于深层毛细血管丛（DCP）和黄斑无血管区（FAZ）的研究结果在不同研究中存在差异。此外，一些研究报告了微血管密度与疾病严重程度之间的相关性。
这些发现支持将OCTA作为一种用于早期诊断和监测PD进展的无创、客观工具，强调了其在疾病临床前期阶段的临床应用潜力。
