College of Chemistry and Chemical Engineering, Inner Mongolia University, Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, PR China.
College of Chemistry and Chemical Engineering, Inner Mongolia University, Engineering Research Center of Dairy Quality and Safety Control Technology, Ministry of Education, Inner Mongolia University, Hohhot 010021, PR China.
Colloids Surf B Biointerfaces. 2024 Sep;241:114037. doi: 10.1016/j.colsurfb.2024.114037. Epub 2024 Jun 13.
Black phosphorus (BP) has attracted much attention due to its excellent physiochemical properties. However, due to its biodegradability and simple antibacterial mechanism, using only BP nanomaterials to combat bacterial infections caused by drug-resistant pathogens remains a significant challenge. In order to improve the antibacterial efficiency and avoid the emergence of drug resistance, BP nanomaterials have been combined with other functional materials to form black phosphorus-based antibacterial nanoplatform (BPANP), which provides unprecedented opportunities for the treatment of drug-resistant infections. This article reviews the performance of BPANP and its multiple antibacterial mechanisms while emphatically introducing its design direction and latest application progress in antibacterial fields. Moreover, this paper additionally summarizes and discusses the current challenges and inadequacies of BPANP that need to be improved in future research. We believe that this review will provide researchers with an up-to-date and multifaceted reference, and provide new ideas for designing effective strategies against drug-resistant bacteria.
黑磷（BP）由于其优异的物理化学性质而受到广泛关注。然而，由于其可生物降解性和简单的抗菌机制，仅使用 BP 纳米材料来对抗由耐药病原体引起的细菌感染仍然是一个重大挑战。为了提高抗菌效率并避免耐药性的出现，BP 纳米材料已与其他功能材料结合形成基于黑磷的抗菌纳米平台（BPANP），这为治疗耐药性感染提供了前所未有的机会。本文综述了 BPANP 的性能及其多种抗菌机制，同时着重介绍了其在抗菌领域的设计方向和最新应用进展。此外，本文还总结和讨论了 BPANP 当前需要在未来研究中改进的挑战和不足之处。我们相信，这篇综述将为研究人员提供最新和全面的参考，并为设计对抗耐药菌的有效策略提供新的思路。
