School of Environment, Beijing Normal University, Beijing 100875, China.
School of Environment, Beijing Normal University, Beijing 100875, China.
Sci Total Environ. 2020 Jun 15;721:137740. doi: 10.1016/j.scitotenv.2020.137740. Epub 2020 Mar 5.
Recently, two-dimensional black phosphorus (BP) nanomaterial has captured much attention due to its superb physiochemical and electronic properties and various promising biomedical applications. However, relatively few studies have explored its antimicrobial properties, particularly for targeting antibiotic-resistant pathogens. A comprehensive understanding of the bactericidal mechanisms of BP is essential for application of this material as an antimicrobial. This review discusses the physicochemical and electronic properties of BP that are relevant for antimicrobial applications, especially the unique characteristics that may play a role in overcoming drug resistance. The literature is discussed in the context of what is known and what information is missing. We also highlight the differences and advantages of BP over other two-dimensional nanomaterials (i.e., graphene oxide and molybdenum disulfide) for bactericidal activity. Finally, we analyze existing challenges and note topics that require future investigation to overcome current inadequacies, aiming to assist the safe development of BP-based nanotechnology for pathogen control.
最近，二维黑磷 (BP) 纳米材料因其出色的物理化学和电子特性以及各种有前途的生物医学应用而引起了广泛关注。然而，相对较少的研究探索了其抗菌特性，特别是针对对抗生素耐药病原体的靶向作用。全面了解 BP 的杀菌机制对于将这种材料作为抗菌剂的应用至关重要。本综述讨论了与抗菌应用相关的 BP 的物理化学和电子特性，特别是可能在克服耐药性方面发挥作用的独特特性。文献讨论的背景是已知的信息和缺失的信息。我们还强调了 BP 与其他二维纳米材料（即氧化石墨烯和二硫化钼）相比在杀菌活性方面的差异和优势。最后，我们分析了现有的挑战，并指出需要未来研究的主题，以克服当前的不足，旨在帮助基于 BP 的纳米技术的安全发展，以控制病原体。
