Geng Yuan-Yuan, Yang Shuo, Liu Zhi-Hao, Wang Si-Yu, Ge Pan
Department of Pathology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, 710004, Shaanxi, China.
Department of Central Laboratory, Huang Gang Hospital of Traditional Chinese Medicine, Huanggang, 438000, Hubei, China.
Dig Dis Sci. 2024 Aug;69(8):2875-2882. doi: 10.1007/s10620-024-08519-1. Epub 2024 Jun 15.
Gastric cancer is a malignant tumor with high morbidity and mortality all around the world. Because of its poor prognosis and low survival rate, the treatment of gastric cancer has received extensive attention. Cinnamaldehyde (CA) is the main single active component of the Chinese herbal medicine cinnamon, which has a variety of pharmacological effects. The inhibitory effect of CA on the growth of some tumor cells has been proven, but its therapeutic effect on gastric cancer has rarely been reported.
Through network pharmacology, bioinformatics methods, and molecular docking technology, we predicted the interaction targets of CA and gastric cancer. Moreover, we found that apoptosis is an important mode of action of CA on gastric cancer cells. Subsequently, we validated it in gastric cancer cell lines cultured in vitro.
The results showed that in the presence of CA, the Jak2/Stat3 pathway was inhibited, the ratio of Bcl-2/Bax decreased, and the apoptosis of gastric cancer cells was promoted in a concentration-dependent.
In conclusion, CA can promote the apoptosis of gastric cancer cells by inhibiting the activity of the Jak2/Stat3 pathway, which may achieve the effect of treating gastric cancer.
胃癌是一种在全球范围内发病率和死亡率都很高的恶性肿瘤。由于其预后较差且生存率低，胃癌的治疗受到了广泛关注。肉桂醛（CA）是中药肉桂的主要单一活性成分，具有多种药理作用。CA对某些肿瘤细胞生长的抑制作用已得到证实，但其对胃癌的治疗作用鲜有报道。
通过网络药理学、生物信息学方法和分子对接技术，我们预测了CA与胃癌的相互作用靶点。此外，我们发现细胞凋亡是CA对胃癌细胞作用的重要方式。随后，我们在体外培养的胃癌细胞系中进行了验证。
结果表明，在CA存在的情况下，Jak2/Stat3信号通路受到抑制，Bcl-2/Bax比值降低，胃癌细胞凋亡呈浓度依赖性增加。
总之，CA可通过抑制Jak2/Stat3信号通路的活性促进胃癌细胞凋亡，这可能达到治疗胃癌的效果。
