Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China; Guangzhou Key Laboratory of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China.
Department of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China; Guangzhou Key Laboratory of Otorhinolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, People's Republic of China; Department of Otorhinolaryngology, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ann Allergy Asthma Immunol. 2024 Nov;133(5):559-567.e3. doi: 10.1016/j.anai.2024.05.023. Epub 2024 Jun 15.
Despite the large patient base in Asia, the prognostic factors of patients with non-eosinophilic chronic rhinosinusitis with nasal polyps (CRSwNPs) remain largely undetermined.
To systematically investigate the predictive value of clinical and biological variables for non-eosinophilic CRSwNP.
A total of 51 patients with non-eosinophilic CRSwNP who underwent functional endoscopic surgery were recruited. Clinical information and assessment were comprehensively collected before and after surgery. A broad spectrum of biomarkers was measured in tissue homogenates using multiple assays. A random forest algorithm and stepwise logistic regression were used to construct clinical, biological, and combined models.
A total of 41.2% patients with non-eosinophilic CRSwNP were uncontrolled more than 6 months after surgery. We identified 1 clinical variable (22-item Sino-Nasal Outcome Test score) and 4 biomarkers (programmed cell death ligand 1, platelet-derived growth factor subunit β [PDGF-β], macrophage inflammatory protein-3b, and PDGF-α) that were significantly predictive of the surgical outcome. The clinical, biological, and combined models had predictive ability with areas under the curve of 0.78, 0.83, and 0.89, respectively. PDGF-β and programmed cell death ligand 1 were identified as independent biomarkers for the prognosis of patients with CRSwNP without considerable eosinophilic infiltration.
This study reveals that clinical and biological factors, such as the 22-item Sino-Nasal Outcome Test score and PDGF-β, are predictive of the postfunctional endoscopic surgical prognosis of patients with non-eosinophilic CRSwNP.
尽管亚洲有大量的患者，但非嗜酸性慢性鼻-鼻窦炎伴鼻息肉（CRSwNPs）患者的预后因素仍很大程度上尚未确定。
系统研究临床和生物学变量对非嗜酸性 CRSwNP 的预测价值。
共招募了 51 名接受功能性内镜手术的非嗜酸性 CRSwNP 患者。在手术前后全面收集临床信息和评估。使用多种检测方法测量组织匀浆中的广泛生物标志物。使用随机森林算法和逐步逻辑回归构建临床、生物学和联合模型。
共有 41.2%的非嗜酸性 CRSwNP 患者在手术后 6 个月以上仍未得到控制。我们确定了 1 个临床变量（22 项 Sino-Nasal Outcome Test 评分）和 4 个生物标志物（程序性细胞死亡配体 1、血小板衍生生长因子亚基 β [PDGF-β]、巨噬细胞炎症蛋白-3b 和 PDGF-α），它们对手术结果具有显著预测性。临床、生物学和联合模型的预测能力曲线下面积分别为 0.78、0.83 和 0.89。PDGF-β 和程序性细胞死亡配体 1 被确定为非嗜酸性浸润的 CRSwNP 患者预后的独立生物标志物。
本研究表明，临床和生物学因素，如 22 项 Sino-Nasal Outcome Test 评分和 PDGF-β，可预测非嗜酸性 CRSwNP 患者功能性内镜手术后的预后。
