Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, 212013, Jiangsu, China.
Department of Laboratory, Lianyungang Oriental Hospital, Lianyungang, 222042, Jiangsu, China.
Eur J Pharmacol. 2024 Sep 5;978:176720. doi: 10.1016/j.ejphar.2024.176720. Epub 2024 Jun 14.
Extracellular vesicles (EVs) are minute sacs released by cells into the extracellular milieu, harboring an array of biomolecules including proteins, nucleic acids, and lipids. Notably, a large number of studies have demonstrated the important involvement of EVs in both physiological and pathological aspects of renal function. EVs can facilitate communication between different renal cells, but it is important to recognize their dual role: they can either transmit beneficial information or lead to renal damage and worsening of existing conditions. The composition of EVs in the context of the kidneys offers valuable insights into the intricate mechanisms underlying specific renal functions or disease states. In addition, mesenchymal stem cell-derived EVs have the potential to alleviate acute and chronic kidney diseases. More importantly, the innate nanoparticle properties of EVs, coupled with their engineering potential, make them effective tools for drug delivery and therapeutic intervention. In this review, we focus on the intricate biological functions of EVs in the kidney. In addition, we explore the emerging role of EVs as diagnostic tools and innovative therapeutic agents in a range of renal diseases.
细胞外囊泡（EVs）是细胞释放到细胞外环境中的微小囊泡，其中包含多种生物分子，包括蛋白质、核酸和脂质。值得注意的是，大量研究表明 EVs 在肾脏功能的生理和病理方面都有重要的参与。EVs 可以促进不同肾细胞之间的通讯，但需要认识到它们的双重作用：它们既可以传递有益的信息，也可以导致肾脏损伤和现有状况的恶化。在肾脏背景下，EVs 的组成提供了对特定肾脏功能或疾病状态下复杂机制的有价值的见解。此外，间充质干细胞衍生的 EVs 有潜力缓解急性和慢性肾脏疾病。更重要的是，EVs 的固有纳米颗粒特性及其工程潜力使其成为药物输送和治疗干预的有效工具。在这篇综述中，我们重点关注 EVs 在肾脏中的复杂生物学功能。此外，我们还探讨了 EVs 作为诊断工具和创新治疗剂在一系列肾脏疾病中的新兴作用。
