Central Laboratory, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
West Coast New Area Center for Disease Prevention and Control, Qingdao, China.
Mol Biochem Parasitol. 2024 Dec;260:111636. doi: 10.1016/j.molbiopara.2024.111636. Epub 2024 Jun 14.
Opisthorchis felineus, Opisthorchis viverrini, and Clonorchis sinensis (family Opisthorchiidae) are parasitic flatworms that pose serious threats to humans in certain countries and cause opisthorchiasis/clonorchiasis. Opisthorchiid flukes parasitize the biliary tract of the host, causing cholangitis, cholecystitis, cholelithiasis and cholangiocarcinoma. In this review, we primarily focus on recent microRNAs (miRNAs) studies of opisthorchiid flukes and their definitive hosts. Many miRNAs are conserved and expressed in a developmentally stage specific manner in the three opisthorchiid flukes, which play important roles in the growth and development of Opisthorchiidae spp., as well as host-pathogen interactions. Some miRNAs might be potential biomarkers related to carcinogenesis of cholangiocarcinoma. Therefore, this review provides the basis for further investigating the roles of miRNAs in opisthorchiid flukes and their definitive hosts, as well as promoting the development of novel approaches to prevent and treat opisthorchiasis/clonorchiasis.
肝片形吸虫、猫后睾吸虫和中华分支睾吸虫（片形科）是寄生在某些国家的人类体内的扁形动物，它们可引起肝片形吸虫病/华支睾吸虫病。片形科吸虫寄生在宿主的胆道系统中，引起胆管炎、胆囊炎、胆结石和胆管癌。在这篇综述中，我们主要关注片形科吸虫及其终宿主的最新 microRNA（miRNA）研究。许多 miRNA 在三种片形科吸虫中具有保守性和发育阶段特异性表达，它们在片形科吸虫的生长和发育以及宿主-病原体相互作用中发挥重要作用。一些 miRNA 可能是与胆管癌发生相关的潜在生物标志物。因此，本综述为进一步研究 miRNA 在片形科吸虫及其终宿主中的作用提供了基础，并促进了预防和治疗肝片形吸虫病/华支睾吸虫病的新方法的发展。
