光子与质子空间分割放疗的起伏。
The Peaks and Valleys of Photon Versus Proton Spatially Fractionated Radiotherapy.
机构信息
Department of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Radiation Oncology, The Johns Hopkins Proton Center, Washington, DC.
Department of Radiation Oncology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Radiation Oncology, The Johns Hopkins Proton Center, Washington, DC.
出版信息
Semin Radiat Oncol. 2024 Jul;34(3):292-301. doi: 10.1016/j.semradonc.2024.04.007.
Spatially-fractionated radiotherapy (SFRT) delivers high doses to small areas of tumor while sparing adjacent tissue, including intervening disease. In this review, we explore the evolution of SFRT technological advances, contrasting approaches with photon and proton beam radiotherapy. We discuss unique dosimetric considerations and physical properties of SFRT, as well as review the preclinical literature that provides an emerging understanding of biological mechanisms. We emphasize crucial areas of future study and highlight clinical trials that are underway to assess SFRT's safety and efficacy, with a focus on immunotherapeutic synergies. The review concludes with practical considerations for SFRT's clinical application, advocating for strategies that leverage its unique dosimetric and biological properties for improved patient outcomes.
空间分割放射治疗（SFRT）在保护肿瘤周围组织的同时，将高剂量传递至小面积的肿瘤区域，包括肿瘤之间的区域。在这篇综述中，我们探讨了 SFRT 技术进步的演变，对比了光子和质子束放射治疗的方法。我们讨论了 SFRT 的独特剂量学考虑因素和物理特性，并回顾了提供对生物学机制的新兴理解的临床前文献。我们强调了未来研究的关键领域，并重点介绍了正在评估 SFRT 的安全性和疗效的临床试验，重点是免疫治疗协同作用。该综述以 SFRT 的临床应用的实际考虑结束，主张利用其独特的剂量学和生物学特性来改善患者的预后。
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