质子治疗中剂量的空间分割：质子微束放射治疗

Spatial fractionation of the dose in proton therapy: Proton minibeam radiation therapy.

作者信息

De Marzi L, Nauraye C, Lansonneur P, Pouzoulet F, Patriarca A, Schneider T, Guardiola C, Mammar H, Dendale R, Prezado Y

机构信息

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France; Institut Curie, university Paris Saclay, PSL Research university, Inserm U 1021-CNRS UMR 3347, Orsay, France.

Centre de protonthérapie d'Orsay, institut Curie, PSL Research university, campus universitaire, bâtiment 101, 91898 Orsay, France.

出版信息

Cancer Radiother. 2019 Oct;23(6-7):677-681. doi: 10.1016/j.canrad.2019.08.001. Epub 2019 Sep 4.

DOI:10.1016/j.canrad.2019.08.001

PMID:31494038

Abstract

In radiation therapy, a renewed interest is emerging for the study of spatially fractionated irradiation. In this article, a few applications using spatial fractionation of the dose will be discussed with a focus on proton minibeam radiation therapy. Examples of calculated dose (1D profiles and 2D dose distributions) and biological evidence obtained so far will be presented for various spatially fractionated techniques GRID, micro- and minibeam radiation therapy. Recent results demonstrating that proton minibeam radiation therapy leads to an increase in normal tissues sparing will be discussed, which opens the door to a dose escalation in the tumour and a possibly efficient treatment of very radioresistant tumours.

摘要

在放射治疗中，对空间分割照射的研究正在重新兴起。在本文中，将讨论一些使用剂量空间分割的应用，重点是质子微束放射治疗。将展示各种空间分割技术（GRID、微束和微束放射治疗）的计算剂量示例（一维剖面和二维剂量分布）以及迄今获得的生物学证据。将讨论最近的结果，这些结果表明质子微束放射治疗会增加正常组织的 sparing，这为肿瘤剂量递增以及可能有效治疗非常抗辐射的肿瘤打开了大门。