Awad Riham, Musa Mazen, Elhoumed Mohamed, Liu Fei, Guo Qingyu
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an 710061, China.
Laboratory Center of Stomatology, College of Stomatology, Xi'an Jiaotong University, Xi'an 710061, China.
Saudi Dent J. 2024 Jun;36(6):821-829. doi: 10.1016/j.sdentj.2024.03.007. Epub 2024 Mar 13.
To evaluate and compare the effectiveness of Endoflas and Zinc Oxide Eugenol (ZOE) as root canal filling materials (RCFMs) for the pulpectomy of deciduous teeth by analyzing multiple clinical and radiographic success and failure follow-ups in previously published studies.
All clinical studies that investigated the pulpectomy of the deciduous teeth of children aged 3-9 years.
The databases used for source identification included MEDLINE (via PubMed), Scopus, Web of Science, and the Cochrane Library. No limitations were imposed on the publication year or language. The selection of studies and extraction of relevant study characteristics were conducted from December 26, 2021, to September 7, 2023. Additionally, the risk of bias (RoB) in the included studies was evaluated by using a RoB instrument (RoB 2). Eligible studies were then combined, and a random-effects model was applied by using the maximum likelihood estimations of log risk ratios and their corresponding 95% confidence intervals.
Of the 3913 records found in the abovementioned databases, nine were eligible for systematic review and eight were eligible for -analysis. The studies included 628 pulpectomies of deciduous molar teeth in children. The overall results showed that compared with Endoflas, ZOE was associated with a higher risk ratio for clinical evaluation (LOG[RR] = 0.06, CI 0.03-0.09, -value 0.001) and radiographic evaluation (LOG[RR] = 0.68, CI 0.35-1.00, -value 0.001). This association was highly significant at 6- and 9-month follow-ups.
Compared with ZOE, Endoflas was associated with a lower risk of the clinical and radiographic failure of deciduous teeth pulpectomy and a 6%-6.8% higher risk ratio, especially at 6- and 9-month follow-ups.
This study suggests the superiority of Endoflas over ZOE as an RCFM for deciduous teeth.
通过分析既往发表研究中的多项临床及影像学成功与失败随访情况，评估并比较Endoflas和氧化锌丁香酚（ZOE）作为乳牙牙髓摘除术根管充填材料（RCFMs）的有效性。
所有调查3至9岁儿童乳牙牙髓摘除术的临床研究。
用于来源识别的数据库包括MEDLINE（通过PubMed）、Scopus、科学网和Cochrane图书馆。对发表年份或语言未设限制。研究的选择和相关研究特征的提取于2021年12月26日至2023年9月7日进行。此外，使用偏倚风险（RoB）工具（RoB 2）评估纳入研究中的偏倚风险。然后将符合条件的研究合并，并通过对数风险比及其相应的95%置信区间的最大似然估计应用随机效应模型。
在上述数据库中找到的3913条记录中，九条符合系统评价标准，八条符合分析标准。这些研究包括对儿童乳牙磨牙进行的628例牙髓摘除术。总体结果显示，与Endoflas相比，ZOE在临床评估（LOG[RR]=0.06，CI 0.03 - 0.09，P值0.001）和影像学评估（LOG[RR]=0.68，CI 0.35 - 1.00，P值0.001）方面的风险比更高。这种关联在6个月和9个月的随访中具有高度显著性。
与ZOE相比，Endoflas与乳牙牙髓摘除术临床和影像学失败风险较低相关，风险比高6% - 6.8%，尤其是在6个月和9个月的随访中。
本研究表明，作为乳牙的根管充填材料，Endoflas优于ZOE。
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