Passl R
Wien Klin Wochenschr Suppl. 1979;102:1-22.
A model of posttraumatic osteomyelitis was developed in 120 Duncan-Hartley guinea-pigs. For this purpose the right femura of all animals were fractured surgically. In 60 guinea-pigs immobilisation of the fractured extremity was omitted, in remaining 60 the medullary space was splinted with intramedullary pin. Each of the two groups was further subdivided in three subgroups, i.s. non infected controls, staphylococcus aureus-infections and escherichia coli-infections. Comparative evaluations were based on ten follow-up studies, nine of which were scheduled for the first three postoperative months and one 12 months after surgery. The overwhelming majority of infected animals developed acute osteomyelitis. This was found to heal within the first three postoperative months in just a few of the animals without intramedullary pinning. In all other animals the condition became chronic and was still demonstrable one year after infection. Follow-up immunological studies were based on bacterial ingestion. An evaluation of opsonic activity against time revealed statistically significant deferences for all groups. Marked depression of opsonic activity within the first 35 postoperative days after intramedullary pinning constituted the most prominent immunological finding.
在120只邓肯 - 哈特利豚鼠身上建立了创伤后骨髓炎模型。为此，对所有动物的右侧股骨进行手术骨折。60只豚鼠未对骨折肢体进行固定，其余60只则用髓内针固定髓腔。两组中的每组又进一步细分为三个亚组，即未感染对照组、金黄色葡萄球菌感染组和大肠杆菌感染组。比较评估基于十次随访研究，其中九次安排在术后前三个月，一次在术后12个月。绝大多数受感染动物发展为急性骨髓炎。仅在少数未进行髓内固定的动物中，急性骨髓炎在术后前三个月内愈合。在所有其他动物中，病情变为慢性，感染后一年仍可检测到。随访免疫研究基于细菌摄取。对调理活性随时间的评估显示所有组之间存在统计学上的显著差异。髓内固定术后前35天内调理活性的明显降低是最突出的免疫学发现。
