McWilliams Daniel F, Georgopoulos Vasileios, Patel Jayamala, Millar Bonnie, Smith Stephanie L, Walsh David A
Pain Centre Versus Arthritis, University of Nottingham, Nottingham, UK.
NIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, UK.
Rheumatology (Oxford). 2024 Dec 1;63(12):3306-3314. doi: 10.1093/rheumatology/keae342.
Neuropathic-like pain, fatigue, cognitive difficulty, catastrophizing, anxiety, sleep disturbance, depression and widespread pain associate with a single factor in people with knee pain. We report the Central Aspects of Pain questionnaire (CAP) to characterize this across painful musculoskeletal conditions.
CAP was derived from the 8-item CAP-Knee questionnaire, and completed by participants with joint pain in the Investigating Musculoskeletal Health and Wellbeing survey. Subgroups had OA, back pain or FM. Acceptability was evaluated by feedback and data missingness. Correlation coefficients informed widespread pain scoring threshold in relation to the other items, and evaluated associations with pain. Factor analysis assessed CAP structure. Intraclass Correlation Coefficient (ICC) between paper and electronic administration assessed reliability. Friedman test assessed score stability over 4 years in people reporting knee OA.
Data were from 3579 participants (58% female, median age 71 years), including subgroups with OA (n = 1158), back pain (n = 1292) or FM (n = 177). Across the three subgroups, ≥10/26 painful sites on the manikin scored widespread pain. Reliability was high [ICC = 0.89 (95% CI 0.84-0.92)] and CAP scores fit to one- and two-factor model, with a total CAP score that was associated with pain severity and quality (r = 0.50-0.72). In people with knee pain, CAP scores were stable over 4 years at the group level, but displayed significant temporal heterogeneity within individual participants.
Central aspects of pain are reliably measured by the CAP questionnaire across a range of painful musculoskeletal conditions, and is a changeable state.
在膝关节疼痛患者中，神经性疼痛、疲劳、认知困难、灾难化思维、焦虑、睡眠障碍、抑郁和广泛性疼痛与单一因素相关。我们报告疼痛问卷的核心方面（CAP），以描述在各种疼痛性肌肉骨骼疾病中的这一情况。
CAP源自8项膝关节CAP问卷，由参与肌肉骨骼健康与幸福调查的关节疼痛参与者完成。亚组包括骨关节炎（OA）、背痛或纤维肌痛（FM）患者。通过反馈和数据缺失情况评估可接受性。相关系数确定了与其他项目相关的广泛性疼痛评分阈值，并评估了与疼痛的关联。因子分析评估CAP结构。通过纸质版和电子版管理之间的组内相关系数（ICC）评估信度。Friedman检验评估报告膝关节OA的患者4年内评分的稳定性。
数据来自3579名参与者（58%为女性，中位年龄71岁），包括OA亚组（n = 1158）、背痛亚组（n = 1292）或FM亚组（n = 177）。在这三个亚组中，人体模型上≥10/26个疼痛部位被评为广泛性疼痛。信度较高[ICC = 0.89（95%CI 0.84 - 0.92）]，CAP评分符合单因素和双因素模型，CAP总分与疼痛严重程度和性质相关（r = 0.50 - 0.72）。在膝关节疼痛患者中，CAP评分在组水平上4年内稳定，但在个体参与者中显示出显著的时间异质性。
CAP问卷可在一系列疼痛性肌肉骨骼疾病中可靠地测量疼痛的核心方面，且这是一种可变状态。
