PMR Department, Marmara University School of Medicine, Istanbul, Turkey.
PMR Department, Rheumatology Division, Marmara University School of Medicine, Istanbul, Turkey.
Mod Rheumatol. 2022 Oct 15;32(6):1137-1145. doi: 10.1093/mr/roab110.
To evaluate the central sensitization (CS) and the related parameters in patients with axial spondyloarthritis (axSpA).
Quantitative sensory testing (QST) which consists of pressure pain threshold (PPT), temporal summation (TS), and conditioned pain modulation (CPM) were applied to the participants. Disease activity, functional status, sleep quality, pain, depression, and fatigue were assessed. Patients were divided as the ones with and without CS according to the central sensitization inventory (CSI) and the results were compared.
One hundred patients and 50 controls were recruited. Sixty axSpA patients had CS. When QST results were compared between the patient and control groups, all PPT scores were found lower (p < 0.05) in patients. Regarding the comparison of the patients with and without CS, sacroiliac, and trapezius PPT scores were found lower in the patients with CS (p < 0.05). There was no significant difference between groups in TS values (p > 0.05). All investigated comorbidities were found to be significantly more frequent (p < 0.001) in the patients with CS.
CS and related comorbidities were found to be increased in axSpA patients. This increase should be taken into consideration in the management of these patients.
评估中轴型脊柱关节炎（axSpA）患者的中枢敏化（CS）及其相关参数。
对参与者进行定量感觉测试（QST），包括压力疼痛阈值（PPT）、时间总和（TS）和条件性疼痛调制（CPM）。评估疾病活动度、功能状态、睡眠质量、疼痛、抑郁和疲劳。根据中枢敏化量表（CSI）将患者分为有 CS 和无 CS 两组，并对结果进行比较。
共招募了 100 名患者和 50 名对照者。60 名 axSpA 患者存在 CS。当将患者组和对照组的 QST 结果进行比较时，发现患者的所有 PPT 评分均较低（p<0.05）。在比较有 CS 和无 CS 的患者时，发现 CS 患者的骶髂和斜方肌 PPT 评分较低（p<0.05）。两组之间的 TS 值无显著差异（p>0.05）。所有调查的合并症在 CS 患者中均明显更为常见（p<0.001）。
在 axSpA 患者中发现 CS 及其相关合并症增加。在这些患者的管理中应考虑到这种增加。
