Department of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 West Taylor St, Applied Health Sciences Building, Room 506J, Chicago IL, 60612, United States.
Department of Physical Therapy, MGH Institute of Health Professions, United States.
Mult Scler Relat Disord. 2024 Aug;88:105715. doi: 10.1016/j.msard.2024.105715. Epub 2024 Jun 9.
The Multiple Sclerosis Walking Scale-12 (MSWS-12) has typically been delivered through paper-and-pencil or computer-based administration.
This study examined the validity of inferences from scores derived via a telephone administration of the MSWS-12 applied as part of screening of participants with walking dysfunction into a clinical trial of exercise training in MS.
The MSWS-12 was administered on two occasions separated by approximately 2 weeks through the telephone and then in-person (i.e., computer-based administration). Participants further completed the Patient Determined Disease Steps (PDDS) scale, timed 25-foot walk (T25FW), six-minute walk (6MW), Modified Fatigue Impact Scale (MFIS), and Multiple Sclerosis Impact Scale-29 (MSIS-29), and underwent a neurological exam for generating an expanded disability status scale (EDSS) score. The primary set of data (Full Sample) for analyses included all persons who passed the telephone screening for inclusion with MSWS-12 scores between 25 and 75 (N = 374). The secondary set of data (Truncated Sample) included only persons with MSWS-12 scores between 25 and 75 for both the telephone and computer administrations of the MSWS-12 (N = 248).
The results in the Full Sample indicated a difference in overall and item levels scores between the telephone and computer data collections, and the computer version had higher internal consistency and stronger unidimensionality. Nevertheless, MSWS-12 scores from both modes of administration had comparable correlations with the T25FW, 6MW, EDSS, PDDS, MFIS, and MSIS-29, but the correlation between the two MSWS-12 administrations did not approach unity. There was a systematic difference in scores between telephone and computer administrations across levels of walking dysfunction based on a Bland-Altman plot, and the difference was predicted by MFIS physical, 6MW, and EDSS scores. The comparison of results between the Full and Truncated Samples suggested that the primary analysis might have been influenced by the larger range of scores on the computer than telephone administrations of the MSWS-12.
The telephone administration of the MSWS-12 provides an efficient and cost-effective measure of walking dysfunction in persons with MS.
多发性硬化症步行量表-12（MSWS-12）通常通过纸质或基于计算机的方式进行管理。
本研究通过电话管理 MSWS-12 来评估从电话管理 MSWS-12 中获得的分数推断的有效性，该管理方法应用于因行走功能障碍而参加运动训练临床试验的参与者的筛选。
通过电话在大约 2 周内两次管理 MSWS-12，然后亲自（即基于计算机的管理）管理。参与者还完成了患者确定疾病步骤（PDDS）量表、25 英尺步行计时（T25FW）、6 分钟步行（6MW）、改良疲劳影响量表（MFIS）和多发性硬化症影响量表-29（MSIS-29），并进行了神经检查以生成扩展残疾状态量表（EDSS）评分。用于分析的主要数据集（完整样本）包括通过电话筛选并通过 MSWS-12 评分在 25 到 75 之间的所有人员（N=374）。辅助数据集（截断样本）仅包括电话和计算机管理 MSWS-12 评分均在 25 到 75 之间的人员（N=248）。
在完整样本中，电话和计算机数据收集的总体和项目水平得分存在差异，计算机版本的内部一致性更高，单维性更强。尽管如此，两种模式管理的 MSWS-12 评分与 T25FW、6MW、EDSS、PDDS、MFIS 和 MSIS-29 的相关性相当，但两种 MSWS-12 管理之间的相关性并未接近统一。根据 Bland-Altman 图，在基于行走障碍程度的得分中，电话和计算机管理之间存在系统差异，并且差异可以通过 MFIS 物理、6MW 和 EDSS 分数预测。完整和截断样本之间结果的比较表明，主要分析可能受到 MSWS-12 计算机管理与电话管理之间更大范围分数的影响。
MSWS-12 的电话管理为多发性硬化症患者的行走功能障碍提供了一种高效、经济有效的测量方法。
