Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL, USA.
Acta Neurol Scand. 2013 Jun;127(6):384-90. doi: 10.1111/ane.12036. Epub 2012 Dec 13.
Accelerometry has been identified as a possible ecologically valid and objective approach for measuring community ambulation in multiple sclerosis (MS). This study provides a validation of accelerometer output based on associations with Expanded Disability Status Scale (EDSS), Patient Determined Disease Steps (PDDS) Scale, and Multiple Sclerosis Walking Scale-12 (MSWS-12) scores, timed 25-foot walk (T25FW) and 6-min walk (6MW) performance, oxygen cost (O(2) cost) of walking, and spatial and temporal parameters of gait.
256 persons with MS completed the PDDS and MSWS-12, underwent an examination for the generation of an EDSS score, undertook two T25FW tests and a 6MW while wearing a portable metabolic unit for measuring the O(2) cost of walking, completed two trials of comfortable walking on a GAITRite electronic walkway for measuring spatial and temporal parameters of gait, and then wore an Actigraph accelerometer during the waking hours of a 7-day period.
The accelerometer output was significantly correlated with EDSS (ρ = -0.522), PDDS (ρ = -0.551), and MSWS-12 (ρ = -0.617) scores, T25FW (ρ = -0.595) and 6MW (ρ = 0.630) performance, and O(2) cost of walking (ρ = -0.457). Regarding gait parameters, the accelerometer output was significantly correlated with velocity (ρ = 0.420), cadence (ρ = 0.349), step time (ρ = -0.353), step length (ρ = 0.395), double support (ρ = -0.424), and single support (ρ = 0.400).
We provide comprehensive evidence from a large sample of persons with MS that further supports accelerometry as a measure of walking behavior.
加速度计已被确定为一种可能的生态有效且客观的方法，可用于测量多发性硬化症（MS）中的社区步行能力。本研究基于与扩展残疾状况量表（EDSS）、患者确定的疾病步骤量表（PDDS）和多发性硬化症步行量表-12（MSWS-12）评分、定时 25 英尺步行（T25FW）和 6 分钟步行（6MW）表现、步行的耗氧量（O(2)消耗）以及步态的时空参数的关联，对加速度计输出进行了验证。
256 名多发性硬化症患者完成了 PDDS 和 MSWS-12，进行了 EDSS 评分生成检查，穿着便携式代谢装置进行了两次 T25FW 测试和 6MW，以测量步行的 O(2)消耗，完成了两次在 GAITRite 电子步道上舒适行走的试验，以测量步态的时空参数，然后在 7 天的清醒时间内佩戴 Actigraph 加速度计。
加速度计输出与 EDSS（ρ=-0.522）、PDDS（ρ=-0.551）和 MSWS-12（ρ=-0.617）评分、T25FW（ρ=-0.595）和 6MW（ρ=0.630）表现以及步行的 O(2)消耗（ρ=-0.457）呈显著相关。关于步态参数，加速度计输出与速度（ρ=0.420）、步频（ρ=0.349）、步时（ρ=-0.353）、步长（ρ=0.395）、双支撑（ρ=-0.424）和单支撑（ρ=0.400）呈显著相关。
我们从大量多发性硬化症患者中提供了综合证据，进一步支持了加速度计作为行走行为测量的方法。
