Department of Microbiology and Immunology, State University of New York Upstate Medical University, Syracuse, NY 13210, USA.
Department of Infectious Diseases, Singapore General Hospital, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore.
Vaccine. 2024 Oct 3;42(23):126071. doi: 10.1016/j.vaccine.2024.06.038. Epub 2024 Jun 17.
The first dengue "endgame" summit was held in Syracuse, NY over August 9 and 10, 2023. Organized and hosted by the Institute for Global Health and Translational Sciences at SUNY Upstate Medical University, the gathering brought together researchers, clinicians, drug and vaccine developers, government officials, and other key stakeholders in the dengue field for a highly collaborative and discussion-oriented event. The objective of the gathering was to discuss the current state of dengue around the world, what dengue "control" might look like, and what a potential roadmap might look like to achieve functional dengue control. Over the course of 7 sessions, speakers with a diverse array of expertise highlighted both current and historic challenges associated with dengue control, the state of dengue countermeasure development and deployment, as well as fundamental virologic, immunologic, and medical barriers to achieving dengue control. While sustained eradication of dengue was considered challenging, attendees were optimistic that significant reduction in the burden of dengue can be achieved by integration of vector control with effective application of therapeutics and vaccines.
2023 年 8 月 9 日至 10 日，第一届登革热“终结”峰会在纽约州锡拉丘兹举行。该活动由纽约州立大学上州医科大学全球健康与转化科学研究所组织和主办，汇集了研究人员、临床医生、药物和疫苗开发商、政府官员和登革热领域的其他关键利益相关者，进行了一次高度协作和以讨论为导向的活动。会议的目的是讨论全球登革热的现状、可能的“控制”模式以及实现功能性登革热控制的潜在路线图。在 7 个会议期间，具有不同专业知识的演讲者强调了与登革热控制相关的当前和历史挑战、登革热对策的开发和部署现状，以及实现登革热控制的基本病毒学、免疫学和医学障碍。虽然持续根除登革热被认为具有挑战性，但与会者乐观地认为，通过将病媒控制与有效的治疗和疫苗应用相结合，可以实现登革热负担的显著减少。
