Torkashvand Zahra, Sepehrmansourie Hassan, Zolfigol Mohammad Ali, Gu Yanlong
Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina University, Hamedan, 6517838683, Iran.
School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, 1037 Luoyu Road, Hongshan District, Wuhan, 430074, China.
Sci Rep. 2024 Jun 19;14(1):14101. doi: 10.1038/s41598-024-62757-x.
The strategy of designing heterogeneous porous catalysts by a post-modification method is a smart strategy to increase the catalytic power of desired catalysts. Accordingly, in this report, metal-organic frameworks based on titanium with acetic acid pending were designed and synthesized via post-modification method. The structure of the target catalyst has been investigated using different techniques such as FT-IR, XRD, SEM, EDX, Mapping, and N adsorption/desorption (BET/the BJH) the correctness of its formation has been proven. The catalytic application of Ti-based MOFs functionalized with acetic acid was evaluated in the preparation of new spiropyrans, and the obtained results show that the catalytic performance is improved by this modification. The strategy of designing heterogeneous porous catalysts through post-modification methods presents a sophisticated approach to enhancing the catalytic efficacy of desired catalysts. In this context, our study focuses on the synthesis and characterization of metal-organic frameworks (MOFs) based on titanium, functionalized with acetic acid pendants, using a post-modification method. Various characterization techniques, including Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray spectroscopy (EDX), mapping, and N adsorption/desorption (BET/BJH), were employed to investigate the structure and composition of the synthesized catalyst. These techniques collectively confirmed the successful formation and structural integrity of the target catalyst. The structure of the synthesized products was confirmed by melting point, H-NMR and C-NMR and FT-IR techniques. Examining the general process of catalyst synthesis and its catalytic application shows that the mentioned modification is very useful for catalytic purposes. The presented catalyst was used in synthesis of a wide range of biologically active spiropyrans with good yields. The simultaneous presence of several biologically active cores in the synthesized products will highlight the biological properties of these compounds. The present study offers a promising insight into the rational design, synthesis, and application of task-specific porous catalysts, particularly in the context of synthesizing biologically active candidate molecules.
通过后修饰方法设计非均相多孔催化剂的策略是提高所需催化剂催化能力的明智策略。因此，在本报告中，通过后修饰方法设计并合成了基于钛且带有乙酸侧基的金属有机框架。使用不同技术（如傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、能量色散X射线光谱（EDX）、图谱分析以及N吸附/脱附（BET/BJH））对目标催化剂的结构进行了研究，证明了其形成的正确性。评估了用乙酸功能化的钛基金属有机框架在制备新型螺吡喃中的催化应用，所得结果表明这种修饰提高了催化性能。通过后修饰方法设计非均相多孔催化剂的策略为增强所需催化剂的催化效果提供了一种复杂的方法。在此背景下，我们的研究重点是使用后修饰方法合成并表征基于钛且带有乙酸侧基的金属有机框架（MOF）。采用了各种表征技术，包括傅里叶变换红外光谱（FT-IR）、X射线衍射（XRD）、扫描电子显微镜（SEM）、能量色散X射线光谱（EDX）、图谱分析以及N吸附/脱附（BET/BJH），以研究合成催化剂的结构和组成。这些技术共同证实了目标催化剂的成功形成及其结构完整性。通过熔点、氢核磁共振（H-NMR）、碳核磁共振（C-NMR）和傅里叶变换红外光谱（FT-IR）技术确认了合成产物的结构。研究催化剂合成的一般过程及其催化应用表明，上述修饰对于催化目的非常有用。所展示的催化剂用于合成多种具有良好产率的生物活性螺吡喃。合成产物中同时存在几个生物活性核心将突出这些化合物的生物学特性。本研究为特定任务的多孔催化剂的合理设计、合成和应用提供了有前景的见解，特别是在合成生物活性候选分子的背景下。
