Department of Surgery, Faculty of Health Sciences, University of Pretoria, Private Bag X323, Pretoria, 0001, South Africa.
Sci Rep. 2024 Jun 18;14(1):14042. doi: 10.1038/s41598-024-64019-2.
Gallstones are common in Western countries and increasing in developing countries through adoption of western lifestyle. Gallstones may cause life-threatening complications, including acute cholecystitis, acute cholangitis, and acute pancreatitis. Cholecystectomy is the treatment of choice for symptomatic gallstones. Presentation of symptomatic gallstones may be indistinguishable from that of other upper gastro-intestinal tract (UGI) pathologies. Some surgeons routinely perform preoperative UGI endoscopy to diagnose and treat concomitant UGI pathology. A prospective cross-sectional observational study was undertaken at University of Pretoria teaching hospitals to evaluate this practice. Patients aged 18 years and older, with symptomatic gallstones but did not satisfy Tokyo guidelines for acute cholecystitis were recruited. UGI endoscopy was performed before cholecystectomy. There were 124 patients, 110 (88.7%) females and 14 (11.3%) males, mean age 44.0 (13.2) (range: 22-78) years. Most common symptoms were right upper quadrant (RUQ) pain (87%), epigastric pain (59.7%), nausea (58.1%) and vomiting (47.9%). Clinically, 80% had RUQ tenderness and 52.4% epigastric tenderness. UGI endoscopy found 35.4% pathology, 28.2% were active, and comprised acute gastritis (27.4%), peptic ulcers (4.8%), duodenitis (3.2%) and oesophagitis (2.4%). Twelve patients had more than one pathology. This warranted treatment before elective cholecystectomy and justifies the practice of routine preoperative UGI endoscopy.
胆囊结石在西方国家很常见,在采用西方生活方式的发展中国家也越来越多。胆囊结石可引起危及生命的并发症,包括急性胆囊炎、急性胆管炎和急性胰腺炎。胆囊切除术是治疗有症状胆囊结石的首选方法。有症状的胆囊结石的表现可能与其他上消化道(UGI)病变无法区分。一些外科医生通常会在术前进行 UGI 内镜检查,以诊断和治疗并存的 UGI 病变。在比勒陀利亚大学教学医院进行了一项前瞻性横断面观察性研究,以评估这种做法。招募了年龄在 18 岁及以上、有症状的胆囊结石但不符合急性胆囊炎东京指南的患者。在胆囊切除术前进行 UGI 内镜检查。共有 124 名患者,110 名(88.7%)为女性,14 名(11.3%)为男性,平均年龄为 44.0(13.2)(范围:22-78)岁。最常见的症状是右上腹(RUQ)疼痛(87%)、上腹痛(59.7%)、恶心(58.1%)和呕吐(47.9%)。临床上,80%的患者有 RUQ 压痛,52.4%的患者有上腹痛。UGI 内镜检查发现 35.4%的病变,28.2%为活动性病变,包括急性胃炎(27.4%)、消化性溃疡(4.8%)、十二指肠炎(3.2%)和食管炎(2.4%)。12 名患者有多种病变。这需要在择期胆囊切除术前进行治疗,证明了术前常规进行 UGI 内镜检查的合理性。