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源自麻风分枝杆菌在背根神经节培养物雪旺细胞中的细胞内增殖。

Intracellular multiplication of leprosy-derived mycobacteria in Schwann cells of dorsal root ganglion cultures.

作者信息

Mukherjee R, Antia N H

出版信息

J Clin Microbiol. 1985 May;21(5):808-14. doi: 10.1128/jcm.21.5.808-814.1985.

DOI:10.1128/jcm.21.5.808-814.1985
PMID:3889048
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC271787/
Abstract

Organized nerve cultures of dorsal root ganglia from neonatal mice were infected with Mycobacterium leprae, the causative agent of leprosy. A significant multiplication of the acid-fast bacilli was observed within the Schwann cell component of the culture. The growth of these bacilli was sensitive to antileprosy drugs and was not observed directly in bacteriological media. These organisms were brightly stained with the monoclonal antibody to phenolic glycolipid-I, a M. leprae-specific marker. The antigenic, pathogenic, and biochemical characteristics of this mycobacterium are under investigation.

摘要

将来自新生小鼠的背根神经节的有组织神经培养物用麻风病的病原体麻风杆菌进行感染。在培养物的雪旺细胞成分内观察到抗酸杆菌的显著增殖。这些杆菌的生长对抗麻风病药物敏感，并且在细菌学培养基中未直接观察到其生长。这些生物体用针对酚糖脂-I的单克隆抗体进行了明亮染色，酚糖脂-I是麻风杆菌的特异性标志物。这种分枝杆菌的抗原性、致病性和生化特性正在研究中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/a912b1593d06/jcm00118-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/50ec73678869/jcm00118-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/da37e875bbf8/jcm00118-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/850eea3f5cc6/jcm00118-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/a912b1593d06/jcm00118-0174-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/50ec73678869/jcm00118-0171-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/da37e875bbf8/jcm00118-0172-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/850eea3f5cc6/jcm00118-0173-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d654/271787/a912b1593d06/jcm00118-0174-a.jpg

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本文引用的文献

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Growth characteristics of an acid-fast Mycobacterium isolated from human lepromatous leprosy.从人类瘤型麻风病中分离出的一种抗酸分枝杆菌的生长特性
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Effect of macrocyclon in acute and chronic pulmonary tuberculous infection in mice as shown by viable and total bacterial counts.通过活菌计数和总细菌计数显示大环内酯对小鼠急性和慢性肺结核感染的影响。
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Behavior of human leprosy bacilli in cultures of human cells.人麻风杆菌在人细胞培养物中的行为
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Effects of a derivative of serotonin (deoxyfructoserotonin) and other antileprosy drugs on attachment and uptake of Mycobacterium leprae by Schwann cells in vitro.血清素衍生物（脱氧果糖血清素）及其他抗麻风病药物对体外雪旺细胞吸附及摄取麻风分枝杆菌的影响。
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Radiolabeling of Mycobacterium leprae lipids within schwannoma cells, a potential drug screening system.雪旺氏细胞瘤细胞内麻风分枝杆菌脂质的放射性标记，一种潜在的药物筛选系统。
Antimicrob Agents Chemother. 1991 Jul;35(7):1444-7. doi: 10.1128/AAC.35.7.1444.
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Phospholipase activity of Mycobacterium leprae harvested from experimentally infected armadillo tissue.从实验感染犰狳组织中收获的麻风分枝杆菌的磷脂酶活性。
Infect Immun. 1991 Aug;59(8):2781-9. doi: 10.1128/iai.59.8.2781-2789.1991.
J Infect Dis. 1959 Jul-Aug;105(1):73-5. doi: 10.1093/infdis/105.1.73.
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A light and electron microscope study of long-term organized cultures of rat dorsal root ganglia.大鼠背根神经节长期组织培养的光镜与电镜研究
J Cell Biol. 1967 Feb;32(2):439-66. doi: 10.1083/jcb.32.2.439.
5
Comparison of nerve cell and nerve cell plus Schwann cell cultures, with particular emphasis on basal lamina and collagen formation.神经细胞与神经细胞加施万细胞培养物的比较，特别强调基膜和胶原蛋白的形成。
J Cell Biol. 1980 Jan;84(1):184-202. doi: 10.1083/jcb.84.1.184.
6
A novel phenolic glycolipid from Mycobacterium leprae possibly involved in immunogenicity and pathogenicity.一种来自麻风分枝杆菌的新型酚糖脂，可能与免疫原性和致病性有关。
J Bacteriol. 1981 Sep;147(3):728-35. doi: 10.1128/jb.147.3.728-735.1981.
7
Incorporation of 3H-thymidine in Mycobacterium leprae within differentiated human macrophages.3H-胸腺嘧啶核苷在分化的人类巨噬细胞内掺入麻风分枝杆菌的情况。
J Med Microbiol. 1981 Aug;14(3):279-93. doi: 10.1099/00222615-14-3-279.
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Organized nerve culture. II. DNA synthesis in Schwann cells in the presence of M. leprae.有组织的神经培养。II. 存在麻风杆菌时雪旺细胞中的DNA合成。
Int J Lepr Other Mycobact Dis. 1980 Jun;48(2):189-92.
9
Organized nerve culture. I. A technique to study the effect of M. leprae infection.有组织的神经培养。I. 一种研究麻风杆菌感染影响的技术。
Int J Lepr Other Mycobact Dis. 1980 Jun;48(2):183-8.
10
Leprosy--a disease of the Schwann cell.麻风病——一种施万细胞疾病。
Lepr India. 1982 Oct;54(4):599-604.