中国咸宁地区妇女高危型人乳头瘤病毒的流行情况及基因型分布。

The prevalence and genotype distribution of high-risk human papillomaviruses among women in Xianning, China.

机构信息

Department of Gynecology, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, Hubei, 437000, China.

出版信息

Virol J. 2024 Jun 18;21(1):140. doi: 10.1186/s12985-024-02413-y.

DOI:10.1186/s12985-024-02413-y

PMID:38890675

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11186159/

Abstract

BACKGROUND

The persistent infection of high-risk Human papillomavirus(HPV) is considered the main cause of cervical intraepithelial neoplasia and cervical cancer. But various cervical lesions caused by HPV infection can be properly prevented by timely vaccination. However, the distribution of HPV genotypes varies geographically.

METHODS

Retrospective analysis of high-risk HPV prevalence of 16,150 women from 2020 to 2022 in xianning of China. HPV genotyping was performed using a PCR-RDB Kit that can detect 18 high-risk HPV genotypes recommended by China's National Medical Products Administration. The prevalence of 18 high-risk HPV genotypes and their relationship with cervical lesions as well as vaccine efficacy were analyzed.

RESULTS

A total of 2431 women were confirmed to have different types of high-risk HPV infections. The overall positive rate reached 15.05%(2431/16,150). The most prevalent high-risk HPV genotypes were HPV52, 16, 58, 53, and 51. The prevalence of high-risk HPV reached peak at age ≤ 20(20.95%) and age ≥ 61(20.56%). The most prevalent high-risk HPV genotypes were HPV16, 58, 18, 33 and 52 in cervical cancer cases, HPV16, 52, 58, 33 and 18 in CIN2/3 cases, and HPV52, 58, 16, 53 and 18 in CIN1 cases, respectively.

CONCLUSION

HPV16, 58 and 18 are the most dangerous and carcinogenic genotypes in xianning, China. Conducting epidemiological investigations on high-risk HPV has significant clinical value in guiding HPV vaccination work.

摘要

背景

高危型人乳头瘤病毒（HPV）的持续感染被认为是导致宫颈上皮内瘤变和宫颈癌的主要原因。但 HPV 感染引起的各种宫颈病变可以通过及时接种疫苗得到适当预防。然而，HPV 基因型的分布在地理上存在差异。

方法

回顾性分析了 2020 年至 2022 年中国咸宁 16150 名女性的高危型 HPV 流行情况。采用 PCR-RDB 试剂盒进行 HPV 基因分型，该试剂盒可检测中国国家药品监督管理局推荐的 18 种高危型 HPV 基因型。分析了 18 种高危型 HPV 基因型的流行情况及其与宫颈病变的关系以及疫苗的有效性。

结果

共有 2431 名女性被确认为患有不同类型的高危型 HPV 感染。总阳性率达到 15.05%（2431/16150）。最常见的高危型 HPV 基因型是 HPV52、16、58、53 和 51。高危型 HPV 的流行率在年龄≤20 岁（20.95%）和年龄≥61 岁（20.56%）达到高峰。宫颈癌病例中最常见的高危型 HPV 基因型是 HPV16、58、18、33 和 52，CIN2/3 病例中最常见的高危型 HPV 基因型是 HPV16、52、58、33 和 18，CIN1 病例中最常见的高危型 HPV 基因型是 HPV52、58、16、53 和 18。