Institute of Biophotonics, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Department of Dermatology, Taipei City Hospital, Taipei, Taiwan.
Lasers Surg Med. 2024 Aug;56(6):557-563. doi: 10.1002/lsm.23812. Epub 2024 Jun 18.
Considering the pulse widths of picosecond and nanosecond lasers used in cutaneous laser surgery differ by approximately one order of magnitude, can nanosecond lasers produce the optical effect in human skin similar to laser-induced optical breakdown (LIOB) caused by picosecond lasers?
Cutaneous changes induced by a focused fractional nanosecond 1064-nm Nd:YAG laser were evaluated by VISIA-CR imaging, histological examination, and harmonic generation microscopy (HGM).
A focused fractional nanosecond 1064-nm Nd:YAG laser can generate epidermal vacuoles or dermal cavities similar to the phenomenon of LIOB produced by picosecond lasers. The location and extent of photodisruption can be controlled by the laser fluence and focus depth. Moreover, laser-induced shock wave propagation and thermal degeneration of papillary collagen can be observed by HGM imaging.
Focused fractional nanosecond lasers can produce an optical effect on human skin similar to LIOB caused by picosecond lasers. With techniques of application, the treatment can induce epidermal and dermal repair mechanisms in a tunable fashion to improve skin texture, wrinkles, scars, and dyspigmentation, without disrupting the epidermal surface.
由于皮秒和纳秒激光在皮肤激光手术中的脉宽相差约一个数量级，纳秒激光能否在人皮肤上产生类似于皮秒激光诱导光击穿（LIOB）的光学效应？
通过 VISIA-CR 成像、组织学检查和二次谐波产生显微镜（HGM）评估聚焦式纳秒 1064nmNd：YAG 激光引起的皮肤变化。
聚焦式纳秒 1064nmNd：YAG 激光可产生类似于皮秒激光产生的 LIOB 的表皮空泡或真皮腔。光离解的位置和程度可以通过激光能量密度和焦点深度来控制。此外，通过 HGM 成像可以观察到激光诱导冲击波的传播和乳头胶原的热变性。
聚焦式纳秒激光可以在人皮肤上产生类似于皮秒激光诱导的 LIOB 的光学效应。通过应用技术，可以以可调的方式诱导表皮和真皮修复机制，改善皮肤质地、皱纹、疤痕和色素沉着不均，而不破坏表皮表面。
