Kim So-Hee, Lee Yoon-Hee, Jeong Mun-Ju, Lee Ye-Jin, Eun Hye-Ran, Kim Su-Min, Baek Jae-Woon, Noh Hyun Ho, Shin Yongho, Choi Hoon
Department of Applied Bioscience, Dong-A University, Busan 49315, Republic of Korea.
Residual Agrochemical Assessment Division, National Institute of Agricultural Sciences, Wanju 55365, Republic of Korea.
Foods. 2024 Jun 1;13(11):1742. doi: 10.3390/foods13111742.
To prevent pesticides from exceeding maximum residue limits (MRLs) in crops during export and shipment, it is necessary to manage residue levels during the pre-harvest stages. Therefore, the Republic of Korea establishes pre-harvest residue limits (PHRLs) per crop and pesticide. This study was conducted to set PHRLs for penthiopyrad and tebufenpyrad in angelica leaves, where the exceedance rates of MRLs are expected to be high. The LOQ of the analytical method used was 0.01 mg/kg and it demonstrated good linearity, with a correlation coefficient of 0.999 or higher within the quantitation range of 0.005 to 0.5 mg/kg. The recovery and storage stability accuracy values were in the range of 94.5-111.1%, within the acceptable range (70-120%, RSD ≤ 20%). The matrix effect for both pesticides was in the medium-to-strong range, and it did not significantly impact the quantitative results as a matrix-matched calibration method was employed. Using the validated method, residue concentrations of penthiopyrad 20 (%) EC and tebufenpyrad 10 (%) EC were analyzed. Both pesticides exhibited a decreasing residue trend over time. In Fields 1-3 and their integrated results, the biological half-life was within 2.6-4.0 days for penthiopyrad and 3.0-4.2 days for tebufenpyrad. The minimum value of the regression coefficient in the dissipation curve regression equation was selected as the dissipation constant. The selected dissipation constants for penthiopyrad in Fields 1-3 and their integration were 0.1221, 0.2081, 0.2162, and 0.1960. For tebufenpyrad, the dissipation constants were 0.1451, 0.0960, 0.1725, and 0.1600, respectively. The dissipation constant was used to calculate PHRL per field. Following the principles of the PHRL proposal process, residue levels (%) on PHI dates relative to MRLs were calculated, and fields for proposing PHRLs were selected. For penthiopyrad, since the residue level (%) was less than 20%, the PHRL for Field 3 with the largest dissipation constant was proposed. For tebufenpyrad, as the residue level (%) exceeded 80%, the PHRL proposal could not established. It is deemed necessary to reassess the MRL and 'guidelines for safe use' for tebufenpyrad in angelica leaves.
为防止农作物在出口和运输过程中农药残留量超过最大残留限量（MRLs），有必要在收获前阶段对残留水平进行管控。因此，大韩民国针对每种作物和农药制定了收获前残留限量（PHRLs）。本研究旨在设定当归叶中戊唑吡虫啉和联苯菊酯的收获前残留限量，预计这两种农药的最大残留限量超标率较高。所采用分析方法的定量限为0.01 mg/kg，在0.005至0.5 mg/kg的定量范围内显示出良好的线性，相关系数为0.999或更高。回收率和储存稳定性准确度值在94.5 - 111.1%范围内，处于可接受范围（70 - 120%，相对标准偏差≤20%）。两种农药的基质效应处于中等到强的范围，由于采用了基质匹配校准方法，其对定量结果没有显著影响。使用经过验证的方法，分析了20%戊唑吡虫啉乳油和10%联苯菊酯乳油的残留浓度。两种农药的残留量均呈现随时间下降的趋势。在第1 - 3块田地及其综合结果中，戊唑吡虫啉的生物半衰期在2.6 - 4.0天内，联苯菊酯的生物半衰期在3.0 - 4.2天内。选择消散曲线回归方程中回归系数的最小值作为消散常数。第1 - 3块田地及其综合结果中戊唑吡虫啉的选定消散常数分别为0.1221、0.2081、0.2162和0.1960。对于联苯菊酯，消散常数分别为0.1451、0.0960、0.1725和0.1600。利用消散常数计算每块田地的收获前残留限量。按照收获前残留限量提议流程的原则，计算了相对于最大残留限量的收获间隔期（PHI）日期的残留水平（%），并选择了提议收获前残留限量的田地。对于戊唑吡虫啉，由于残留水平（%）低于20%，提议了消散常数最大的第3块田地的收获前残留限量。对于联苯菊酯，由于残留水平（%）超过80%，无法确定收获前残留限量提议。认为有必要重新评估当归叶中联苯菊酯的最大残留限量和“安全使用指南”。
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