Szarka Agneša, Hrouzková Svetlana
Institute of Analytical Chemistry, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, 812 37 Bratislava, Slovakia.
Foods. 2024 Jun 2;13(11):1745. doi: 10.3390/foods13111745.
The production of nutraceuticals is a growing trend, as many consumers consider them an important part of the modern active lifestyle. Others rely on the use of nutraceuticals instead of prescribing pharmaceuticals to improve their health more naturally. One of the major concerns in the nutraceutical industry is the potential presence of contaminants. Even low concentrations of contaminant residues can be harmful, so analytical methods that are sensitive at ultratrace levels are needed. Dispersive liquid-liquid microextraction method combined with fast gas chromatography and mass spectrometry was developed for the inspection of pesticide residues in Carmelite drops. The most suitable recoveries are presented when the alcohol content is fixed at 20% in Carmelite drops. The method was validated; the linearity, limits of detection/quantification, the method accuracy and precision were obtained. The complex nutraceutical matrix causes significant complications in quantitative analysis; therefore, the main target of the work was placed on studying the effects of the matrix on the correct expression of the resulting concentration of contaminants in different types of samples. An in-depth study of matrix factors was carried out, and its relationship with the content of potential interferents from the medicinal products as well as other components added during the drops' production was discussed. Related medicinal plant-derived nutraceuticals were tested, the method was applied for real-life samples, and positive findings are herein reported.
营养保健品的生产是一个不断发展的趋势，因为许多消费者认为它们是现代积极生活方式的重要组成部分。其他人则依赖使用营养保健品而非处方药来更自然地改善健康状况。营养保健品行业的一个主要担忧是可能存在污染物。即使是低浓度的污染物残留也可能有害，因此需要超痕量水平灵敏的分析方法。开发了分散液液微萃取法结合快速气相色谱和质谱法用于检测卡梅尔滴剂中的农药残留。当卡梅尔滴剂中的酒精含量固定在20%时，回收率最为合适。该方法经过验证，获得了线性、检测/定量限、方法准确性和精密度。复杂的营养保健品基质在定量分析中会导致重大并发症；因此，这项工作的主要目标是研究基质对不同类型样品中污染物最终浓度正确表达的影响。对基质因素进行了深入研究，并讨论了其与药品中潜在干扰物含量以及滴剂生产过程中添加的其他成分的关系。对相关药用植物来源的营养保健品进行了测试，该方法应用于实际样品，并在此报告了阳性结果。
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