Frederick National Laboratory, Frederick, MD 21701, USA.
School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Cells. 2024 May 22;13(11):891. doi: 10.3390/cells13110891.
BACH2 (BTB Domain and CNC Homolog 2) is a transcription factor that serves as a central regulator of immune cell differentiation and function, particularly in T and B lymphocytes. A picture is emerging that BACH2 may function as a master regulator of cell fate that is exquisitely sensitive to cell activation status. In particular, BACH2 plays a key role in stabilizing the phenotype and suppressive function of transforming growth factor-beta (TGF-β)-derived human forkhead box protein P3 (FOXP3) inducible regulatory T cells (iTregs), a cell type that holds great clinical potential as a cell therapeutic for diverse inflammatory conditions. As such, BACH2 potentially could be targeted to overcome the instability of the iTreg phenotype and suppressive function that has hampered their clinical application. In this review, we focus on the role of BACH2 in T cell fate and iTreg function and stability. We suggest approaches to modulate BACH2 function that may lead to more stable and efficacious Treg cell therapies.
BACH2（BTB 结构域和 CNC 同源物 2）是一种转录因子，作为免疫细胞分化和功能的中央调节剂，特别是在 T 和 B 淋巴细胞中。有一个观点正在浮现，即 BACH2 可能作为细胞命运的主调控因子发挥作用，对细胞激活状态非常敏感。特别是，BACH2 在稳定转化生长因子-β（TGF-β）衍生的人叉头框蛋白 P3（FOXP3）诱导的调节性 T 细胞（iTreg）的表型和抑制功能方面发挥关键作用，作为一种细胞治疗方法，iTreg 在多种炎症条件下具有巨大的临床潜力。因此，BACH2 可能成为一个潜在的靶点，以克服阻碍其临床应用的 iTreg 表型和抑制功能的不稳定性。在这篇综述中，我们重点关注 BACH2 在 T 细胞命运和 iTreg 功能和稳定性中的作用。我们提出了调节 BACH2 功能的方法，这些方法可能会导致更稳定和有效的 Treg 细胞治疗。
