Kranenburg Lieuwke Cecilia, Bouwmeester Bo F, van den Boom Robin
Department of Clinical Sciences, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 112, 3584 CM Utrecht, The Netherlands.
Animals (Basel). 2024 May 30;14(11):1638. doi: 10.3390/ani14111638.
Inflammatory bowel disease (IBD) is a chronic disease characterized by different cell infiltrates in the intestine. The aims of this study were to report the clinical and clinicopathological findings in horses with histological changes compatible with IBD in the duodenum. Further, the clinical progression of IBD and survival were investigated. Patient records were reviewed for horses in which histological evidence of IBD was found in duodenal biopsies collected during endoscopy. The histological changes were classified as mild, moderate or severe and the predominant infiltrating cell type was recorded. Clinical improvement was assessed by the owner via a questionnaire at 6 weeks after biopsy, along with survival after one year. In total, 149 horses were included, and the most common clinical signs were weight loss, reduced performance and pain during abdominal palpation. Most horses showed partial malabsorption during an oral glucose absorption test, and the horses with severe IBD had lower serum protein concentrations. Lymphoplasmacytic enteritis was the most common type of IBD (78.5% of cases), while in six horses neutrophilic infiltration of the duodenum was present. Overall, 71% of the cases had improved clinically after six weeks, mostly following treatment with corticosteroids. The results of a second biopsy were a poor predictor of improvement, and the horses that improved after 6 weeks were more likely to be alive after one year.
炎症性肠病（IBD）是一种以肠道内不同细胞浸润为特征的慢性疾病。本研究的目的是报告十二指肠组织学变化与IBD相符的马匹的临床和临床病理特征。此外，还对IBD的临床进展和存活率进行了调查。回顾了在内镜检查期间采集的十二指肠活检中发现IBD组织学证据的马匹的病历。将组织学变化分为轻度、中度或重度，并记录主要浸润细胞类型。活检后6周，通过主人填写问卷评估临床改善情况，并记录一年后的存活率。总共纳入了149匹马，最常见的临床症状是体重减轻、性能下降和腹部触诊时疼痛。大多数马匹在口服葡萄糖吸收试验中表现出部分吸收不良，患有严重IBD的马匹血清蛋白浓度较低。淋巴细胞性浆细胞性肠炎是最常见的IBD类型（78.5%的病例），而有6匹马十二指肠存在中性粒细胞浸润。总体而言，71%的病例在6周后临床症状有所改善，大多是在接受皮质类固醇治疗后。第二次活检结果对改善情况的预测性较差，6周后有所改善的马匹在一年后存活的可能性更大。
