Leach Jeremiah, Suber Hannah N, Banks Emilynn, Kaskocsak Ashley, Valencia Henry, Hames Benjamin, Rivera Regan, Colette Sarah, Kendall Ronald J
Wildlife Toxicology Laboratory, Texas Tech University, 1234 Davis Dr., Lubbock, TX 79416, USA.
Animals (Basel). 2024 Jun 1;14(11):1659. doi: 10.3390/ani14111659.
is a heteroxenous nematode that infects the harderian gland and other ocular tissues in birds. High-intensity infections often cause damage to the infected tissues. Due to the nature of the infection sites, treatment of in these hosts can be difficult. Fenbendazole (FBZ) is a common anthelmintic used to treat birds for helminth infections; however, little information exists as to the efficacy of the drug on infections. The present study aims to estimate lethal concentrations of FBZ to . Adult were maintained in vitro and exposed to doses of 5, 50, 100, and 200 µM concentrations of FBZ and included both negative and vehicle controls. Exposure lasted 7.5 days and lethality was determined for each treatment. Negative and vehicle controls did not differ, and both had 75% survival at the end of the treatment period. The percentage survivorship in ascending order of concentration, corrected for the controls, was 66.67%, 44.44%, 33.33%, and 0%. LC, LC, and LC estimates were 7.5 ± 0.26, 49.1 ± 1.69, and 163.2 ± 5.63 µM, respectively. In the context of known pharmacokinetics of FBZ in birds, a single oral dose of FBZ can achieve exposure levels that are lethal to , but the drug does not stay in the system long enough. Thus, treatment of infections will require multiple oral doses over several days.
是一种异宿主线虫，可感染鸟类的哈德氏腺和其他眼部组织。高强度感染通常会对受感染组织造成损害。由于感染部位的性质，在这些宿主中治疗该线虫可能很困难。芬苯达唑（FBZ）是一种常用的驱虫药，用于治疗鸟类的蠕虫感染；然而，关于该药物对该线虫感染的疗效信息很少。本研究旨在估计FBZ对该线虫的致死浓度。将成年该线虫在体外饲养，并暴露于5、50、100和200μM浓度的FBZ剂量下，同时设置阴性和溶媒对照。暴露持续7.5天，并确定每种处理的致死率。阴性和溶媒对照无差异，在处理期结束时两者的存活率均为75%。按浓度升序排列并经对照校正后的存活百分比分别为66.67%、44.44%、33.33%和0%。LC₅₀、LC₉₀和LC₉₉估计值分别为7.5±0.26、49.1±1.69和163.2±5.63μM。在已知FBZ在鸟类中的药代动力学情况下，单次口服FBZ可达到对该线虫致死的暴露水平，但药物在体内停留的时间不够长。因此，治疗该线虫感染需要在几天内多次口服给药。
