GDF15，肾脏生理学和病理生理学中的新兴角色。

GDF15, an Emerging Player in Renal Physiology and Pathophysiology.

机构信息

Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

Centre de Recherche des Cordeliers, Institut National de la Santé et de la Recherche Scientifique (INSERM), Sorbonne Université, Université Paris Cité, Laboratoire de Physiologie Rénale et Tubulopathies, F-75006 Paris, France.

出版信息

Int J Mol Sci. 2024 May 29;25(11):5956. doi: 10.3390/ijms25115956.

DOI:10.3390/ijms25115956

PMID:38892145

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11172470/

Abstract

These last years, the growth factor GDF15 has emerged as a key element in many different biological processes. It has been established as being produced in response to many pathological states and is now referred to as a stress-related hormone. Regarding kidney functions, GDF15 has been involved in different pathologies such as chronic kidney disease, diabetic nephropathy, renal cancer, and so on. Interestingly, recent studies also revealed a role of GDF15 in the renal homeostatic mechanisms allowing to maintain constant, as far as possible, the plasma parameters such as pH and K values. In this review, we recapitulate the role of GDF15 in physiological and pathological context by focusing our interest on its renal effect.

摘要

近年来，生长因子 GDF15 已成为许多不同生物学过程中的关键要素。它已被确定为对许多病理状态产生反应，现在被称为应激相关激素。关于肾脏功能，GDF15 已参与多种病理状态，如慢性肾脏病、糖尿病肾病、肾细胞癌等。有趣的是，最近的研究还揭示了 GDF15 在肾脏稳态机制中的作用，使尽可能使血浆参数如 pH 值和 K 值保持恒定。在这篇综述中，我们通过关注其肾脏效应，总结了 GDF15 在生理和病理环境中的作用。