Department of Biomedical and Forensic Sciences, University of Cape Coast, Cape Coast P.O. Box CCLN 33, Ghana.
Department of Medicine, Surgery and Health Sciences, University of Trieste, Strada di Fiume 447, I-34149 Trieste, Italy.
Int J Mol Sci. 2024 Jun 6;25(11):6283. doi: 10.3390/ijms25116283.
Ovarian cancer (OC) remains the most fatal disease of gynaecologic malignant tumours. The neovasculature in the tumour microenvironment principally comprises endothelial cells. Haematogenous cancer metastases are significantly impacted by tumour neovascularisation, which predominantly depends on the tumour-derived endothelial vasculogenesis. There is an urgent need for biomarkers for the diagnosis, prognosis and prediction of drug response. Endothelial cells play a key role in angiogenesis and other forms of tumour vascularisation. Subtypes of circulating endothelial cells may provide interesting non-invasive biomarkers of advanced OC that might have the potential to be included in clinical analysis for patients' stratification and therapeutic management. In this review, we summarise the reported studies on circulating endothelial subtypes in OC, detailing their isolation methods as well as their potential diagnostic, prognostic, predictive and therapeutic utility for clinical application. We highlight key biomarkers for the identification of circulating endothelial cell subtypes and their targets for therapies and critically point out future challenges.
卵巢癌（OC）仍然是妇科恶性肿瘤中最致命的疾病。肿瘤微环境中的新血管主要由内皮细胞组成。肿瘤血管生成显著影响血源性癌症转移，而肿瘤血管生成主要依赖于肿瘤源性内皮血管生成。因此，迫切需要用于诊断、预后和预测药物反应的生物标志物。内皮细胞在血管生成和其他形式的肿瘤血管生成中发挥关键作用。循环内皮细胞的亚型可能为晚期 OC 提供有趣的非侵入性生物标志物，这些标志物有可能被纳入患者分层和治疗管理的临床分析中。在这篇综述中，我们总结了关于 OC 中循环内皮亚型的报道研究，详细介绍了它们的分离方法以及它们在临床应用中的潜在诊断、预后、预测和治疗用途。我们强调了用于鉴定循环内皮细胞亚型的关键生物标志物及其治疗靶点，并批判性地指出了未来的挑战。
