Medicinal Biosciences, Department of Applied Biological Sciences, Graduate School, BK21 Program, Konkuk University, Chungju 27478, Republic of Korea.
Human Bioscience Corporate R&D Center, Human Bioscience Corp., 268 Chungwondaero, Chungju 27478, Republic of Korea.
Nutrients. 2024 May 21;16(11):1554. doi: 10.3390/nu16111554.
Alzheimer's disease (AD) is the most common form of dementia and neurogenerative disease (NDD), and it is also one of the leading causes of death worldwide. The number of AD patients is over 55 million according to 2020 Alzheimer's Disease International (ADI), and the number is increasing drastically without any effective cure. In this review, we discuss and analyze the potential role of anthocyanins (ACNs) against AD while understanding the molecular mechanisms. ACNs have been reported as having neuroprotective effects by mitigating cognitive impairments, apoptotic markers, neuroinflammation, aberrant amyloidogenesis, and tauopathy. Taken together, ACNs could be an important therapeutic agent for combating or delaying the onset of AD.
阿尔茨海默病（AD）是最常见的痴呆和神经退行性疾病（NDD），也是全球主要死因之一。根据 2020 年国际阿尔茨海默病协会（ADI）的数据，AD 患者超过 5500 万，而且没有有效的治疗方法，患者数量还在急剧增加。在这篇综述中，我们讨论和分析了花色苷（ACNs）在了解其分子机制的情况下对抗 AD 的潜在作用。已有报道称花色苷具有神经保护作用，可减轻认知障碍、凋亡标志物、神经炎症、异常淀粉样蛋白形成和tau 病。总的来说，花色苷可能是对抗或延缓 AD 发病的重要治疗药物。
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