Shanghai Food Safety and Engineering Technology Research Center, Bor S. Luh Food Safety Research Center, Key Lab of Urban Agriculture (South), School of Agriculture & Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
J Agric Food Chem. 2023 Oct 18;71(41):15064-15072. doi: 10.1021/acs.jafc.3c03183. Epub 2023 Oct 2.
Red cabbage anthocyanins may provide health benefits that may be associated with antiaging. The protection of red cabbage anthocyanin-rich extract (ARE) and cyanidin-3-diglucoside-5-glucoside-rich extract (CY3D5G) against age-related cognitive dysfunction was investigated in normal aging mice (male C57BL/6J, 12 months old) administered orally for 12 weeks. Behavioral tests showed that ARE and CY3D5G significantly decreased cognitive impairment ( < 0.05) and had no effect on motor disorder. ARE and CY3D5G increased superoxide dismutase activity by 29.18 and 23.09% and decreased malondialdehyde by 15.74 and 10.05%, respectively, compared to the control. Histological staining showed that ARE and CY3D5G treatment reduced hippocampal neuronal damage and brain-derived neurotrophic factor degeneration. ARE and CY3D5G significantly reduced IL-1β and IL-6 levels in serum and brain ( < 0.05) by promoting the MAPK signaling pathway while enriching the abundance of butyrate-producing bacteria and altering the functional profile of the microbial community. In conclusion, ARE and CY3D5G may attenuate age-related cognitive dysfunction by reducing neuroinflammation and regulating the gut-brain axis.
红甘蓝花色苷可能具有抗衰老相关的健康益处。本研究旨在探讨富含红甘蓝花色苷的提取物（ARE）和矢车菊素-3-二葡萄糖苷-5-葡萄糖苷丰富的提取物（CY3D5G）对正常衰老小鼠（雄性 C57BL/6J，12 个月大）的口服给药 12 周后，对年龄相关认知功能障碍的保护作用。行为测试表明，ARE 和 CY3D5G 可显著降低认知障碍（<0.05），且对运动障碍无影响。与对照组相比，ARE 和 CY3D5G 分别使超氧化物歧化酶活性增加 29.18%和 23.09%，丙二醛降低 15.74%和 10.05%。组织学染色显示，ARE 和 CY3D5G 可减少海马神经元损伤和脑源性神经营养因子退化。ARE 和 CY3D5G 通过促进 MAPK 信号通路显著降低血清和脑中的 IL-1β和 IL-6 水平（<0.05），同时丰富了产生丁酸盐的细菌丰度，并改变了微生物群落的功能特征。总之，ARE 和 CY3D5G 可能通过减轻神经炎症和调节肠道-大脑轴来减轻与年龄相关的认知功能障碍。
