George Emil Palade University of Medicine Pharmacy, Science and Technology of Targu Mures, 540142 Targu Mures, Romania.
Doctoral School of Biomedical Sciences, University of Oradea, 410087 Oradea, Romania.
Nutrients. 2024 Jun 3;16(11):1753. doi: 10.3390/nu16111753.
(1) Background: Urinary tract infections (UTIs) are among otherwise healthy women represent a problem that requires additional understanding and approaches. Evidencing the link between dysbiosis and UTIs and the associated potential risk factors could lead to therapeutic approaches with increased efficiency under the conditions of reducing the risks associated with antibiotic treatments. The purpose of this study was to evaluate dysbiosis and other potential risk factors in women with a history of urinary tract infections; (2) Methods: Fecal dysbiosis tests were performed comparatively in two groups of women. The first group in-cluded women with recurrent urinary tract infections (rUTI) who had either two or more symp-tomatic episodes of UTI in the previous six months. The second group included women with spo-radic UTIs who did not have >1 UTI during a 12-month period and who did not have another UTI in the last 12 months; (3) Results: An association was shown between intestinal dysbiosis and recurrences of urinary tract infections. Increased body weight was associated with intestinal dysbiosis. Also, the lack of knowledge regarding the risk of using antibiotics and the benefits of probiotics was associated with both dysbiosis and recurrences of urinary tract infections; (4) Conclusions: Dysbiosis can have an impact on the recurrence of urinary tract infections. The risk factors for rUTI and dysbiosis in the sphere of lifestyle are potentially controllable, broadening the perspective for new approaches and changing the paradigm in the treatment of urinary tract infections.
(1) 背景：在健康女性中，尿路感染 (UTI) 是一个需要进一步理解和处理的问题。证明肠道菌群失调与 UTI 之间的联系以及相关的潜在风险因素，可能会导致在降低抗生素治疗相关风险的情况下，提高治疗效率的治疗方法。本研究的目的是评估有尿路感染史的女性的肠道菌群失调和其他潜在风险因素；(2) 方法：对两组女性进行了粪便菌群失调测试。第一组包括复发性尿路感染 (rUTI) 患者，她们在过去六个月中有两次或两次以上有症状的 UTI 发作。第二组包括偶发性 UTI 患者，她们在 12 个月内没有 >1 次 UTI，并且在过去 12 个月内没有再次发生 UTI；(3) 结果：肠道菌群失调与尿路感染的复发之间存在关联。体重增加与肠道菌群失调有关。此外，对使用抗生素的风险和益生菌的益处缺乏了解与肠道菌群失调和尿路感染的复发有关；(4) 结论：肠道菌群失调可能会影响尿路感染的复发。rUTI 和生活方式领域中肠道菌群失调的风险因素是潜在可控的，为新方法提供了更广阔的视角，并改变了尿路感染的治疗模式。
