Division of Urogynecology and Reconstructive Pelvic Surgery, David Geffen School of Medicine at UCLA, Box 951738, Los Angeles, CA 90095-1738, USA.
Division of Urogynecology and Reconstructive Pelvic Surgery, David Geffen School of Medicine at UCLA, Box 951738, Los Angeles, CA 90095-1738, USA.
Urol Clin North Am. 2024 Nov;51(4):525-536. doi: 10.1016/j.ucl.2024.07.016.
Although antibiotics remain the mainstay of urinary tract infection treatment, many affected women can be caught in a vicious cycle in which antibiotics given to eradicate one infection predispose them to develop another. This effect is primarily mediated by disturbances in the gut microbiome that both directly enrich for uropathogenic overgrowth and induce systemic alterations in inflammation, tissue permeability, and metabolism that also decrease host resistance to infection recurrences. Here, we discuss nonantibiotic approaches to manipulating the gut microbiome to reverse the systemic consequences of antibiotics, including cranberry supplementation and other dietary approaches, probiotic administration, and fecal microbiota transplantation.
尽管抗生素仍然是尿路感染治疗的主要方法，但许多受影响的女性可能陷入恶性循环，即用于消除一种感染的抗生素使她们更容易发生另一种感染。这种影响主要是由肠道微生物组的紊乱介导的，这些紊乱既直接促进了尿路病原体的过度生长，又引起了全身炎症、组织通透性和代谢的改变，从而降低了宿主对感染复发的抵抗力。在这里，我们讨论了非抗生素方法来操纵肠道微生物组，以逆转抗生素的全身影响，包括蔓越莓补充剂和其他饮食方法、益生菌的管理以及粪便微生物群移植。
