Wong Shannon, Thanigaimani Shivshankar, Charles James, Whaleboat Donald, Golledge Jonathan
Queensland Research Centre for Peripheral Vascular Disease, College of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia.
First Peoples Health Unit, Griffith University, Brisbane, QLD 4222, Australia.
J Clin Med. 2024 Jun 5;13(11):3339. doi: 10.3390/jcm13113339.
This retrospective analysis of an ongoing prospective cohort study aimed to assess the outcome of revascularisation for treating lifestyle-limiting intermittent claudication caused by peripheral artery disease (PAD) in Aboriginal and Torres Strait Islander Peoples and non-Indigenous North Queenslanders. Consenting patients with PAD who underwent endovascular or open revascularisation procedures for treating lifestyle-limiting intermittent claudication were included. The primary outcome measure was major adverse limb events (MALEs), defined as major amputation or the requirement for repeat open or endovascular revascularisation. Of the 378 included patients, 18 (4.8%) identified as Aboriginal and/or Torres Strait Islander Peoples. During a mean follow-up (standard deviation) of 6.0 (3.9) years, the incidence of MALE was similar in the Aboriginal and Torres Strait Islander People and non-Indigenous Australians (absolute percentage: 50.0% vs. 40.6%, log rank = 0.59). In both unadjusted and adjusted analyses, Aboriginal and Torres Strait Islander Peoples and non-Indigenous Australians had similar risks of MALE (unadjusted hazard ratio, HR, 1.20, 95% confidence interval, CI, 0.61, 2.36; adjusted HR 1.02, 95%CI 0.50, 2.06). This study suggests that Aboriginal and Torres Strait Islander People are under-represented in the population of patients undergoing revascularisation to treat intermittent claudication. Due to small numbers it cannot be reliably concluded that Aboriginal and Torres Strait Islander People and non-Indigenous Australians have similar rates of MALE.
这项对一项正在进行的前瞻性队列研究的回顾性分析旨在评估血管重建术治疗原住民和托雷斯海峡岛民以及非原住民北昆士兰人因外周动脉疾病（PAD）导致的影响生活方式的间歇性跛行的效果。纳入了因治疗影响生活方式的间歇性跛行而接受血管内或开放性血管重建手术的同意参与的PAD患者。主要结局指标是严重肢体不良事件（MALE），定义为大截肢或再次进行开放性或血管内血管重建术的需求。在378名纳入患者中，18名（4.8%）被认定为原住民和/或托雷斯海峡岛民。在平均随访（标准差）6.0（3.9）年期间，原住民和托雷斯海峡岛民以及非原住民澳大利亚人的MALE发生率相似（绝对百分比：50.0%对40.6%，对数秩检验=0.59）。在未调整和调整分析中，原住民和托雷斯海峡岛民以及非原住民澳大利亚人发生MALE的风险相似（未调整风险比，HR，1.20，95%置信区间，CI，0.61，2.36；调整后HR 1.02，95%CI 0.50，2.06）。这项研究表明，在接受血管重建术治疗间歇性跛行的患者群体中，原住民和托雷斯海峡岛民的代表性不足。由于数量较少，无法可靠地得出原住民和托雷斯海峡岛民与非原住民澳大利亚人发生MALE的比率相似的结论。
