Yoon Hyukjin, Lee Seul Ki, Kim Jee-Young, Joo Min Wook
Division of Nuclear Medicine, Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Cancers (Basel). 2024 May 22;16(11):1968. doi: 10.3390/cancers16111968.
(1) Background: it is challenging to determine the accurate grades of cartilaginous bone tumors. Using bone single photon emission computed tomography (SPECT)/computed tomography (CT), maximum standardized uptake value (SUVmax) was found to be significantly associated with different grades of cartilaginous bone tumor. The inquiry focused on the effect of the tumor matrix on SUVmax. (2) Methods: a total of 65 patients from 2017 to 2022 with central cartilaginous bone tumors, including enchondromas and low-to-intermediate grade chondrosarcomas, who had undergone bone SPECT/CT were retrospectively enrolled. The SUVmax was recorded and any aggressive CT findings of cartilaginous bone tumor and Hounsfield units (HU) of the chondroid matrix as mean, minimum, maximum, and standard deviation (SD) were reviewed on CT scans. Pearson's correlation analysis was performed to determine the relationship between CT features and SUVmax. Subgroup analysis was also performed between the benign group (enchondroma) and the malignant group (grade 1 and 2 chondrosarcoma) for comparison of HU values and SUVmax. (3) Results: a significant negative correlation between SUVmax and HU measurements, including HUmax, HUmean, and HU, was found. The subgroup analysis showed significantly higher SUVmax in the malignant group, with more frequent CT aggressive features, and significantly lower HU in the malignant group than in the benign group. (4) Conclusions: it was observed that higher SUVmax and lower HU were associated with a higher probability of having a low-to-intermediate chondrosarcoma with aggressive features and a less calcified tumor matrix.
(1) 背景：确定软骨性骨肿瘤的准确分级具有挑战性。使用骨单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）发现，最大标准化摄取值（SUVmax）与不同分级的软骨性骨肿瘤显著相关。该研究聚焦于肿瘤基质对SUVmax的影响。(2) 方法：回顾性纳入了2017年至2022年期间共65例患有中央型软骨性骨肿瘤（包括内生软骨瘤和低至中级软骨肉瘤）且接受过骨SPECT/CT检查的患者。记录SUVmax，并在CT扫描上复查软骨性骨肿瘤的任何侵袭性CT表现以及类软骨基质的亨氏单位（HU），包括平均值、最小值、最大值和标准差（SD）。进行Pearson相关性分析以确定CT特征与SUVmax之间的关系。还在良性组（内生软骨瘤）和恶性组（1级和2级软骨肉瘤）之间进行亚组分析，以比较HU值和SUVmax。(3) 结果：发现SUVmax与HU测量值（包括HUmax、HUmean和HU）之间存在显著负相关。亚组分析显示，恶性组的SUVmax显著更高，具有更频繁的CT侵袭性特征，且恶性组的HU显著低于良性组。(4) 结论：观察到较高的SUVmax和较低的HU与具有侵袭性特征且肿瘤基质钙化较少的低至中级软骨肉瘤的可能性较高相关。
