Division of Nuclear Medicine, Department of Radiology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Division of Nuclear Medicine, Department of Radiology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Sci Rep. 2020 Jun 29;10(1):10587. doi: 10.1038/s41598-020-67506-4.
Although differentiation between central chondroid tumors is important, their parallelism makes it a diagnostic conundrum for clinicians and radiologists. The objective of this study was to evaluate the efficiency of quantitative single photon emission computed tomography (SPECT)/computed tomography (CT) in differentiating grade I chondrosarcomas from enchondromas. We reviewed SPECT/CT images of patients with enchondromas and grade I chondrosarcomas arising in the long bones. Volume, mean standardized uptake value (SUVmean), and maximum standardized uptake value (SUVmax) of tumors were calculated from SPECT/CT images. In addition, clinical characteristics and radiological information were assessed. Of a total of 34 patients, 14 had chondrosarcomas. Chondrosarcoma group had significantly larger volume, and higher SUVmean and SUVmax of tumors than enchondroma group. There was no significant difference in age and tumor size between two groups. Areas under the receiver-operating characteristic curve (AUCs) for tumor volume, SUVmean, and SUVmax were 0.727, 0.757, and 0.875. In pairwise analyses, SUVmax had larger AUC than SUVmean (p = 0.0216). With a cut-off value of 15.6 for SUVmax, its sensitivity and specificity were 86% and 75% for differentiating between enchondroma and grade I chondrosarcoma. Quantitative SPECT/CT is a potential method to differentiate grade I chondroarcomas from enchondromas in patients with central chondroid tumors.
虽然中央性软骨肿瘤的鉴别很重要，但它们的相似性使得临床医生和放射科医生在诊断上感到困惑。本研究的目的是评估定量单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）在区分 I 级软骨肉瘤和内生软骨瘤中的效率。我们回顾了长骨内生软骨瘤和 I 级软骨肉瘤患者的 SPECT/CT 图像。从 SPECT/CT 图像中计算肿瘤的体积、平均标准化摄取值（SUVmean）和最大标准化摄取值（SUVmax）。此外，还评估了临床特征和影像学信息。在总共 34 名患者中，有 14 名患有软骨肉瘤。与内生软骨瘤组相比，软骨肉瘤组肿瘤的体积、SUVmean 和 SUVmax 均显著增大。两组间的年龄和肿瘤大小无显著差异。肿瘤体积、SUVmean 和 SUVmax 的受试者工作特征曲线（AUC）下面积分别为 0.727、0.757 和 0.875。两两分析中，SUVmax 的 AUC 大于 SUVmean（p=0.0216）。SUVmax 的截断值为 15.6 时，其鉴别内生软骨瘤和 I 级软骨肉瘤的灵敏度和特异性分别为 86%和 75%。定量 SPECT/CT 是区分中央性软骨肿瘤患者 I 级软骨肉瘤和内生软骨瘤的一种有潜力的方法。
