Navasardyan Inesa, Zaravinos Apostolos, Bonavida Benjamin
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Department of Microbiology, Immunology & Molecular Genetics, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Cancers (Basel). 2024 May 30;16(11):2074. doi: 10.3390/cancers16112074.
The transcription factor Yin Yang 1 (YY1) plays a pivotal role in the pathogenesis of glioblastoma multiforme (GBM), an aggressive form of brain tumor. This review systematically explores the diverse roles of YY1 overexpression and activities in GBM, including its impact on the tumor microenvironment (TME) and immune evasion mechanisms. Due to the poor response of GBM to current therapies, various findings of YY1-associated pathways in the literature provide valuable insights into novel potential targeted therapeutic strategies. Moreover, YY1 acts as a significant regulator of immune checkpoint molecules and, thus, is a candidate therapeutic target in combination with immune checkpoint inhibitors. Different therapeutic implications targeting YY1 in GBM and its inherent associated challenges encompass the use of nanoparticles, YY1 inhibitors, targeted gene therapy, and exosome-based delivery systems. Despite the inherent complexities of such methods, the successful targeting of YY1 emerges as a promising avenue for reshaping GBM treatment strategies, presenting opportunities for innovative therapeutic approaches and enhanced patient outcomes.
转录因子阴阳1（YY1）在多形性胶质母细胞瘤（GBM）（一种侵袭性脑肿瘤）的发病机制中起关键作用。本综述系统地探讨了YY1过表达和活性在GBM中的多种作用，包括其对肿瘤微环境（TME）和免疫逃逸机制的影响。由于GBM对当前治疗反应不佳，文献中关于YY1相关途径的各种研究结果为新型潜在靶向治疗策略提供了有价值的见解。此外，YY1作为免疫检查点分子的重要调节因子，因此是与免疫检查点抑制剂联合使用的候选治疗靶点。针对GBM中YY1的不同治疗意义及其固有的相关挑战包括使用纳米颗粒、YY1抑制剂、靶向基因治疗和基于外泌体的递送系统。尽管这些方法存在固有的复杂性，但成功靶向YY1成为重塑GBM治疗策略的一个有前景的途径，为创新治疗方法和改善患者预后提供了机会。
